753499-14-8
Chemical Structure
NS-6740 hydrochloride
- CAS No.: 753499-14-8
- Formula:C19H20ClF3N2O2
- Molecular Weight:400.82
IUPAC Name: (1,4-diazabicyclo[3.2.2]nonan-4-yl)(5-(3-(trifluoromethyl)phenyl)furan-2-yl)methanone hydrochloride
InChIKey: QHSRBONTAYCFCC-UHFFFAOYSA-N
SMILES: O=C(N1CCN2CCC1CC2)C3=CC=C(C4=CC(C(F)(F)F)=CC=C4)O3.Cl
Biological Activity: NS-6740 hydrochloride is a silent agonist of α7 nicotinic acetylcholine receptor (α7 nAChR) with an IC50 of 3 nM. NS-6740 hydrochloride reduces LPS-induced TNF-α release and regulates the cholinergic anti-inflammatory pathway. NS-6740 hydrochloride exerts anti-inflammatory effects. NS-6740 hydrochloride reduces long-term potentiation in hippocampal brain slices. NS-6740 hydrochloride can be used in research related to neuroinflammation and schizophrenia[1][2][3].
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NS-6740 hydrochloride | NS-6740 hydrochloride is a silent agonist of α7 nicotinic acetylcholine receptor (α7 nAChR) with an IC50 of 3 nM. NS-6740 hydrochloride reduces LPS-induced TNF-α release and regulates the cholinergic anti-inflammatory pathway. NS-6740 hydrochloride exerts anti-inflammatory effects. NS-6740 hydrochloride reduces long-term potentiation in hippocampal brain slices. NS-6740 hydrochloride can be used in research related to neuroinflammation and schizophrenia. | |||||||||||||||||||||
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References
- [1]. Thomsen MS, et al. The α7 nicotinic acetylcholine receptor ligands methyllycaconitine, NS6740 and GTS-21 reduce lipopolysaccharide-induced TNF-α release from microglia. Journal of neuroimmunology. 2012 Oct 15;251(1-2):65-72. [Content Brief]
- [2]. Papke RL, et al. NS6740, an α7 nicotinic acetylcholine receptor silent agonist, disrupts hippocampal synaptic plasticity. Neuroscience letters. 2018 Jun 11;677:6-13. [Content Brief]
- [3]. Bristow LJ, et al. The Novel, Nicotinic Alpha7 Receptor Partial Agonist, BMS-933043, Improves Cognition and Sensory Processing in Preclinical Models of Schizophrenia. PloS one. 2016;11(7):e0159996.
