2. MAPK/ERK Pathway Stem Cell/Wnt Apoptosis Immunology/Inflammation
  3. MAP3K ERK TNF Receptor Interleukin Related
  4. Cot-IN-4

Cot-IN-4 (compound 32) is a potent cancer osaka thyroid (COT) kinase inhibitor with an IC50 of 6 nM. Cot-IN-4 inhibits the phosphorylation of ERK (IC50: 60 nM) and inhibits TNFα release (IC50: 60 nM). Cot-IN-4 also inhibits the formation of the pro-inflammatory cytokine IL-1β (IC50: 0.2 μM) in Uric acid (HY-B2130)-stimulated macrophages. Cot-IN-4 can be used for the study of inflammatory diseases.

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Cot-IN-4

Cot-IN-4 Chemical Structure

CAS No. : 1984784-10-2

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Cot-IN-4 Related Antibodies

Top Publications Citing Use of Products

View All MAP3K Isoform Specific Products:

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MAP3K7/TAK1 MAP3K8/COT/Tpl2 MAP3K6/ASK2 MAP3K5/ASK1 MAP3K12/DLK/Pref-1 NIK/MAP3K14

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ERK ERK1 ERK2 ERK5 ERK8

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TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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Description

Cot-IN-4 (compound 32) is a potent cancer osaka thyroid (COT) kinase inhibitor with an IC50 of 6 nM. Cot-IN-4 inhibits the phosphorylation of ERK (IC50: 60 nM) and inhibits TNFα release (IC50: 60 nM). Cot-IN-4 also inhibits the formation of the pro-inflammatory cytokine IL-1β (IC50: 0.2 μM) in Uric acid (HY-B2130)-stimulated macrophages. Cot-IN-4 can be used for the study of inflammatory diseases[1].

IC50 & Target[1]

MAP3K8/COT/Tpl2

 

ERK

 

IL-1β

 

TNF-α

 

Molecular Weight

516.60

Formula

C30H28N8O
CAS No.
SMILES

CC(CN1CCOCC1)NC2=CC=C3C(C=CC(N4C=NC5=C4C6=C(N=C5)C=NC(C7=CC=NC=C7)=C6)=C3)=N2
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cot-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cot-IN-41984784-10-2MAP3KERKTNF ReceptorInterleukin RelatedMAP kinase kinase kinase, MEKK, MAPKKKExtracellular signal regulated kinasesTumor Necrosis Factor ReceptorTNFRILCOT kinase inhibitorphosphorylation of ERKTNFα releaseIL-1βinflammatory diseasesInhibitorinhibitorinhibit

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