1984784-10-2
Chemical Structure
Cot-IN-4
- CAS No.: 1984784-10-2
- Formula:C30H28N8O
- Molecular Weight:516.60
InChIKey: ZMWQOLGHIDQXCJ-UHFFFAOYSA-N
SMILES: CC(CN1CCOCC1)NC2=CC=C3C(C=CC(N4C=NC5=C4C6=C(N=C5)C=NC(C7=CC=NC=C7)=C6)=C3)=N2
Biological Activity: Cot-IN-4 (compound 32) is a potent cancer osaka thyroid (COT) kinase inhibitor with an IC50 of 6 nM. Cot-IN-4 inhibits the phosphorylation of ERK (IC50: 60 nM) and inhibits TNFα release (IC50: 60 nM). Cot-IN-4 also inhibits the formation of the pro-inflammatory cytokine IL-1β (IC50: 0.2 μM) in Uric acid (HY-B2130)-stimulated macrophages. Cot-IN-4 can be used for the study of inflammatory diseases[1].
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Cot-IN-4 | Cot-IN-4 (compound 32) is a potent cancer osaka thyroid (COT) kinase inhibitor with an IC50 of 6 nM. Cot-IN-4 inhibits the phosphorylation of ERK (IC50: 60 nM) and inhibits TNFα release (IC50: 60 nM). Cot-IN-4 also inhibits the formation of the pro-inflammatory cytokine IL-1β (IC50: 0.2 μM) in Uric acid (HY-B2130)-stimulated macrophages. Cot-IN-4 can be used for the study of inflammatory diseases. | |||||||||||||||||||||
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Keywords
