Hibiscetin 

Hibiscetin is an orally active anti-inflammatory, antioxidant, antihyperglycemic, hypolipidemic, hepatoprotective and neuroprotective agent. Hibiscetin reduces the levels of TNF-α, IL-1β and IL-6. Hibiscetin inhibits lipid peroxidation, reduces MDA levels, and induces the activities of antioxidant enzymes CAT, GSH and SOD. Hibiscetin lowers blood glucose, reverses reduced insulin levels, regulates adipokine levels, and reduces elevated AST and ALT levels. Hibiscetin alleviates Rotenone (HY-B1756)-induced akinesia and catalepsy, normalizes neurotransmitter levels, and modulates the activities of activated caspase 3 and BDNF. Hibiscetin can be used in the research of type 2 diabetes, Parkinson's disease and Huntington's disease^[1][2][3][4].

Hibiscetin exhibits high antioxidant activity, with the 8-OH position as the preferred site for radical attack^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Hibiscetin (10 mg/kg; p.o.; daily; 42 days) exerts significant antidiabetic, hypolipidemic, antioxidant, anti-inflammatory, and hepatoprotective effects in high-fat diet/Streptozotocin (HY-13753)-induced type 2 diabetic male Wistar rats^[1].
Hibiscetin (10 mg/kg; p.o.; daily; 42 days) significantly improved lipid profile parameters in male Wistar rats^[1].
Hibiscetin (10 mg/kg; p.o.; daily; 28 days) exerts anti-Parkinsonian activity in Rotenone (HY-B1756)-induced parkinsonism in rats, significantly reducing catalepsy and akinesia, restoring endogenous antioxidant and neurotransmitter levels, lowering oxidative/nitrative stress and neuroinflammatory cytokines, and improving neuronal histopathology^[3].
Hibiscetin (10 mg/kg; p.o.; daily; 15 days) provides significant neuroprotection in 3-Nitropropionic acid (HY-W012875)-induced Huntington's disease in male Wistar rats by restoring body weight, normalizing oxidative stress markers, monoamine neurotransmitters, BDNF, caspase 3, and proinflammatory cytokine levels^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

334.24

C₁₅H₁₀O₉

577-24-2

O=C1C(O)=C(OC=2C(O)=C(O)C=C(O)C12)C=3C=C(O)C(O)=C(O)C3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Gilani SJ, et al. The ameliorative role of hibiscetin against high-fat diets and streptozotocin-induced diabetes in rodents via inhibiting tumor necrosis factor-α, interleukin-1β, and malondialdehyde level. Processes, 2022, 10(7): 1396.

  [2]. Ragi C, et al. Antioxidant activity of Hibiscetin and Hibiscitrin: insight from DFT, NCI, and QTAIM. Theoretical Chemistry Accounts, 2023, 142(3): 30.

  [3]. Alzarea SI, et al. Hibiscetin attenuates oxidative, nitrative stress and neuroinflammation via suppression of TNF-α signaling in rotenone induced parkinsonism in rats. Saudi Pharm J. 2022;30(12):1710-1717.

  [4]. Mahdi WA, et al. Neuroprotectant Effects of Hibiscetin in 3-Nitropropionic Acid-Induced Huntington's Disease via Subsiding Oxidative Stress and Modulating Monoamine Neurotransmitters in Rats Brain. Molecules. 2023;28(3):1402. Published 2023 Feb 1.