Hibiscetin
Hibiscetin is an orally active anti-inflammatory, antioxidant, antihyperglycemic, hypolipidemic, hepatoprotective and neuroprotective agent. Hibiscetin reduces the levels of TNF-α, IL-1β and IL-6. Hibiscetin inhibits lipid peroxidation, reduces MDA levels, and induces the activities of antioxidant enzymes CAT, GSH and SOD. Hibiscetin lowers blood glucose, reverses reduced insulin levels, regulates adipokine levels, and reduces elevated AST and ALT levels. Hibiscetin alleviates Rotenone (HY-B1756)-induced akinesia and catalepsy, normalizes neurotransmitter levels, and modulates the activities of activated caspase 3 and BDNF. Hibiscetin can be used in the research of type 2 diabetes, Parkinson's disease and Huntington's disease.
For research use only. We do not sell to patients.
- CAS No.: 577-24-2
- Formula: C15H10O9
- Molecular Weight:334.24
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Caspase Isoforms
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Biological Activity
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IL-6 |
IL-1β |
TNF-α |
Caspase 3 |
Hibiscetin exhibits high antioxidant activity, with the 8-OH position as the preferred site for radical attack[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Hibiscetin (10 mg/kg; p.o.; daily; 42 days) significantly improved lipid profile parameters in male Wistar rats[1].
Hibiscetin (10 mg/kg; p.o.; daily; 28 days) exerts anti-Parkinsonian activity in Rotenone (HY-B1756)-induced parkinsonism in rats, significantly reducing catalepsy and akinesia, restoring endogenous antioxidant and neurotransmitter levels, lowering oxidative/nitrative stress and neuroinflammatory cytokines, and improving neuronal histopathology[3].
Hibiscetin (10 mg/kg; p.o.; daily; 15 days) provides significant neuroprotection in 3-Nitropropionic acid (HY-W012875)-induced Huntington's disease in male Wistar rats by restoring body weight, normalizing oxidative stress markers, monoamine neurotransmitters, BDNF, caspase 3, and proinflammatory cytokine levels[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar (male, 10-12 weeks old, 150-200 g, high-fat diet + Streptozotocin (HY-13753)-induced type 2 diabetes)[1]
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Dosage:10 mg/kg
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Administration:p.o.; daily; 42 days
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Result:Produced a significant reduction in body weight.
Significantly reduced elevated blood glucose levels and increased lowered serum insulin levels.
Significantly reduced elevated total cholesterol and triglyceride levels, increased lowered high-density lipoprotein cholesterol levels, and reduced elevated total protein levels.
Significantly reduced elevated hepatic malondialdehyde levels, and increased lowered superoxide dismutase, glutathione, and catalase activity.
Significantly reduced elevated serum tumor necrosis factor-α, interleukin-1β, and interleukin-6 levels.
Significantly increased lowered serum adiponectin and leptin levels, and reduced elevated serum resistin levels.
Significantly reduced elevated serum aspartate aminotransferase and alanine aminotransferase levels.
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Animal Model:Wistar (male, 10-12 weeks old, 150-200 g)[1]
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Dosage:10 mg/kg
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Administration:p.o.; daily; 42 days
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Result:Produced a significant reduction in lipid profile parameters.
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Animal Model:Wistar (male, 180 g)[4]
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Dosage:10 mg/kg
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Administration:p.o.; daily; 15 days
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Result:Restored body weight and reversed 3‑nitropropionic acid–induced weight loss.
Reduced brain lipid peroxidation and restored antioxidant biomarkers.
Normalized monoamine neurotransmitter levels.
Reduced cleaved caspase 3 activity and restored BDNF levels.
Reduced proinflammatory markers.
Chemical Information
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CAS No. 577-24-2
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Molecular Weight 334.24
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Formula C15H10O9
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SMILES
O=C1C(O)=C(OC=2C(O)=C(O)C=C(O)C12)C=3C=C(O)C(O)=C(O)C3
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[3]. Alzarea SI, et al. Hibiscetin attenuates oxidative, nitrative stress and neuroinflammation via suppression of TNF-α signaling in rotenone induced parkinsonism in rats. Saudi Pharm J. 2022;30(12):1710-1717. [Content Brief]
[4]. Mahdi WA, et al. Neuroprotectant Effects of Hibiscetin in 3-Nitropropionic Acid-Induced Huntington's Disease via Subsiding Oxidative Stress and Modulating Monoamine Neurotransmitters in Rats Brain. Molecules. 2023;28(3):1402. Published 2023 Feb 1. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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