577-24-2
Chemical Structure
Hibiscetin
- CAS No.: 577-24-2
- Formula:C15H10O9
- Molecular Weight:334.24
IUPAC Name: 3,5,7,8-tetrahydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one
InChIKey: ZPFXBGIJKDANBP-UHFFFAOYSA-N
SMILES: O=C1C(O)=C(OC=2C(O)=C(O)C=C(O)C12)C=3C=C(O)C(O)=C(O)C3
Biological Activity: Hibiscetin is an orally active anti-inflammatory, antioxidant, antihyperglycemic, hypolipidemic, hepatoprotective and neuroprotective agent. Hibiscetin reduces the levels of TNF-α, IL-1β and IL-6. Hibiscetin inhibits lipid peroxidation, reduces MDA levels, and induces the activities of antioxidant enzymes CAT, GSH and SOD. Hibiscetin lowers blood glucose, reverses reduced insulin levels, regulates adipokine levels, and reduces elevated AST and ALT levels. Hibiscetin alleviates Rotenone (HY-B1756)-induced akinesia and catalepsy, normalizes neurotransmitter levels, and modulates the activities of activated caspase 3 and BDNF. Hibiscetin can be used in the research of type 2 diabetes, Parkinson's disease and Huntington's disease[1][2][3][4].
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Hibiscetin | Hibiscetin is an orally active anti-inflammatory, antioxidant, antihyperglycemic, hypolipidemic, hepatoprotective and neuroprotective agent. Hibiscetin reduces the levels of TNF-α, IL-1β and IL-6. Hibiscetin inhibits lipid peroxidation, reduces MDA levels, and induces the activities of antioxidant enzymes CAT, GSH and SOD. Hibiscetin lowers blood glucose, reverses reduced insulin levels, regulates adipokine levels, and reduces elevated AST and ALT levels. Hibiscetin alleviates Rotenone (HY-B1756)-induced akinesia and catalepsy, normalizes neurotransmitter levels, and modulates the activities of activated caspase 3 and BDNF. Hibiscetin can be used in the research of type 2 diabetes, Parkinson's disease and Huntington's disease. | |||||||||||||||||||||
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- [1]. Gilani SJ, et al. The ameliorative role of hibiscetin against high-fat diets and streptozotocin-induced diabetes in rodents via inhibiting tumor necrosis factor-α, interleukin-1β, and malondialdehyde level. Processes, 2022, 10(7): 1396.
- [2]. Ragi C, et al. Antioxidant activity of Hibiscetin and Hibiscitrin: insight from DFT, NCI, and QTAIM. Theoretical Chemistry Accounts, 2023, 142(3): 30.
- [3]. Alzarea SI, et al. Hibiscetin attenuates oxidative, nitrative stress and neuroinflammation via suppression of TNF-α signaling in rotenone induced parkinsonism in rats. Saudi Pharm J. 2022;30(12):1710-1717. [Content Brief]
- [4]. Mahdi WA, et al. Neuroprotectant Effects of Hibiscetin in 3-Nitropropionic Acid-Induced Huntington's Disease via Subsiding Oxidative Stress and Modulating Monoamine Neurotransmitters in Rats Brain. Molecules. 2023;28(3):1402. Published 2023 Feb 1. [Content Brief]
Keywords
