2. Apoptosis
  3. Caspase TNF Receptor
  4. (-)-Isoproterenol hydrochloride

(-)-Isoproterenol hydrochloride  (Synonyms: Levisoprenaline hydrochloride; Proternol L hydrochloride)

Cat. No.: HY-B1670A Purity: 99.61%
COA
SDS
Handling Instructions Technical Support

(-)-Isoproterenol (Levisoprenalinel) hydrochloride is the R-isomer of Isoproterenol. (-)-Isoproterenol hydrochloride can reduce the cleavage of caspase 3 and TNFα levels in retinal endothelial cells (REC). (-)-Isoproterenol hydrochloride can be used for the study of diabetic retinopathy.

For research use only. We do not sell to patients.

(-)-Isoproterenol hydrochloride

(-)-Isoproterenol hydrochloride Chemical Structure

CAS No. : 5984-95-2

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (-)-Isoproterenol hydrochloride:

(-)-Isoproterenol hydrochloride Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE (-)-Isoproterenol hydrochloride

View All Caspase Isoform Specific Products:

View All Isoforms
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

View All TNF Receptor Isoform Specific Products:

View All Isoforms
TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

(-)-Isoproterenol (Levisoprenalinel) hydrochloride is the R-isomer of Isoproterenol. (-)-Isoproterenol hydrochloride can reduce the cleavage of caspase 3 and TNFα levels in retinal endothelial cells (REC). (-)-Isoproterenol hydrochloride can be used for the study of diabetic retinopathy[1].

IC50 & Target[1]

Caspase 3

 

TNF-α

 

In Vitro

(-)-Isoproterenol (R-1) (10 μM; 15-45 minutes) hydrochloride decreases both TNFα and caspase 3 levels in REC and Müller cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(-)-Isoproterenol hydrochloride Related Antibodies

ELISA Assay[1]

Cell Line: REC cells and Müller cells
Concentration: 10 μM
Incubation Time: 15, 30, and 45 minutes
Result: Significantly decreased caspase 3 levels in REC.
Did not significantly decreased the cleaved caspase 3 levels in Müller cells.
Molecular Weight

247.72

Formula

C11H18ClNO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=CC=C([C@@H](O)CNC(C)C)C=C1O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (403.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 100 mg/mL (403.68 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0368 mL 20.1841 mL 40.3682 mL
5 mM 0.8074 mL 4.0368 mL 8.0736 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.97%

SDS (394 KB)

COA (248 KB) HNMR (273 KB) LCMS (87 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 4.0368 mL 20.1841 mL 40.3682 mL 100.9204 mL
5 mM 0.8074 mL 4.0368 mL 8.0736 mL 20.1841 mL
10 mM 0.4037 mL 2.0184 mL 4.0368 mL 10.0920 mL
15 mM 0.2691 mL 1.3456 mL 2.6912 mL 6.7280 mL
20 mM 0.2018 mL 1.0092 mL 2.0184 mL 5.0460 mL
25 mM 0.1615 mL 0.8074 mL 1.6147 mL 4.0368 mL
30 mM 0.1346 mL 0.6728 mL 1.3456 mL 3.3640 mL
40 mM 0.1009 mL 0.5046 mL 1.0092 mL 2.5230 mL
50 mM 0.0807 mL 0.4037 mL 0.8074 mL 2.0184 mL
60 mM 0.0673 mL 0.3364 mL 0.6728 mL 1.6820 mL
80 mM 0.0505 mL 0.2523 mL 0.5046 mL 1.2615 mL
100 mM 0.0404 mL 0.2018 mL 0.4037 mL 1.0092 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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(-)-Isoproterenol hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-Isoproterenol5984-95-2LevisoprenalineProternol LCaspaseTNF ReceptorTumor Necrosis Factor ReceptorTNFRcaspase 3TNFαdiabetic retinopathyInhibitorinhibitorinhibit

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