Tricin 7-O-β-D-glucopyranoside

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Tricin 7-O-β-D-glucopyranoside is a potent and orally active neuroprotective agent. Tricin 7-O-β-D-glucopyranoside induces Apoptosis. Tricin 7-O-β-D-glucopyranoside decreases the expression of TNF-α induced phosphor-κB-α, phosphor-NF-κB, HMGB1.

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Tricin 7-O-β-D-glucopyranoside 화학구조

CAS No. : 32769-01-0

사이즈	가격	재고
1 mg		Ask For Quote & Lead Time
5 mg		Ask For Quote & Lead Time

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

In Vitro

Tricin 7-O-β-D-glucopyranoside (4-64 µM; 12 h) induces apoptosis in a dose-dependent manner after oxygen-glucose deprivation for 3 h followed by 12 h incubation in SH-SY5Y cells^[1].
Tricin 7-O-β-D-glucopyranoside (16, 32 µM; 12 h) decreases the expression of TNF-α (20 ng/ml for 30 min) induced phosphor-κB-α, phosphor-NF-κB, HMGB1 in SH-SY5Y cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:	SH-SY5Y cells
Concentration:	2, 4, 8, 16, 32, 64 µM
Incubation Time:	12 h
Result:	Induced cell apoptosis after oxygen-glucose deprivation for 3 h followed by 12 h incubation with neurobasal medium with the apoptosis rate of 35.6%.

Western Blot Analysis^[1]

Cell Line:	SH-SY5Y cells
Concentration:	16, 32 µM
Incubation Time:	12 h
Result:	Blocked TNF-α (20 ng/ml for 30 min) induced IκB-α and NF-κB phosphorylation, and reduced HMGB1 expression.

In Vivo

Tricin 7-O-β-D-glucopyranoside (50, 100, 200 and 400 mg/kg; p.o.) shows neuroprotective potential in rats with ischemia and reperfusion (I/R)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult male Sprague-Dawley rats^[1]
Dosage:	50, 100, 200 and 400 mg/kg
Administration:	P.o.
Result:	Decreased neurological deficit scores, reduced brain infarct volume and brain water content, inhibited NF-κB activation and reduced HMGB1 expression.

분자량

492.43

화학식

C₂₃H₂₄O₁₂

CAS No.

32769-01-0

SMILES

O=C1C2=C(O)C=C(O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO)C=C2OC(C4=CC(OC)=C(C(OC)=C4)O)=C1

Structure Classification

Initial Source

선적

Room temperature in continental US; may vary elsewhere.

보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Jiang WL, et al. Tricin 7-glucoside protects against experimental cerebral ischemia by reduction of NF-κB and HMGB1 expression. Eur J Pharm Sci. 2012 Jan 23;45(1-2):50-7. [Content Brief]