2. Apoptosis
  3. Apoptosis
  4. Tricin 7-O-β-D-glucopyranoside

Tricin 7-O-β-D-glucopyranoside is a potent and orally active neuroprotective agent. Tricin 7-O-β-D-glucopyranoside induces Apoptosis. Tricin 7-O-β-D-glucopyranoside decreases the expression of TNF-α induced phosphor-κB-α, phosphor-NF-κB, HMGB1.

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Tricin 7-O-β-D-glucopyranoside Chemical Structure

Tricin 7-O-β-D-glucopyranoside Chemical Structure

CAS No. : 32769-01-0

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Tricin 7-O-β-D-glucopyranoside Related Antibodies

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Description

Tricin 7-O-β-D-glucopyranoside is a potent and orally active neuroprotective agent. Tricin 7-O-β-D-glucopyranoside induces Apoptosis. Tricin 7-O-β-D-glucopyranoside decreases the expression of TNF-α induced phosphor-κB-α, phosphor-NF-κB, HMGB1[1].

In Vitro

Tricin 7-O-β-D-glucopyranoside (4-64 µM; 12 h) induces apoptosis in a dose-dependent manner after oxygen-glucose deprivation for 3 h followed by 12 h incubation in SH-SY5Y cells[1].
Tricin 7-O-β-D-glucopyranoside (16, 32 µM; 12 h) decreases the expression of TNF-α (20 ng/ml for 30 min) induced phosphor-κB-α, phosphor-NF-κB, HMGB1 in SH-SY5Y cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tricin 7-O-β-D-glucopyranoside Related Antibodies

Apoptosis Analysis[1]

Cell Line: SH-SY5Y cells
Concentration: 2, 4, 8, 16, 32, 64 µM
Incubation Time: 12 h
Result: Induced cell apoptosis after oxygen-glucose deprivation for 3 h followed by 12 h incubation with neurobasal medium with the apoptosis rate of 35.6%.

Western Blot Analysis[1]

Cell Line: SH-SY5Y cells
Concentration: 16, 32 µM
Incubation Time: 12 h
Result: Blocked TNF-α (20 ng/ml for 30 min) induced IκB-α and NF-κB phosphorylation, and reduced HMGB1 expression.
In Vivo

Tricin 7-O-β-D-glucopyranoside (50, 100, 200 and 400 mg/kg; p.o.) shows neuroprotective potential in rats with ischemia and reperfusion (I/R)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague-Dawley rats[1]
Dosage: 50, 100, 200 and 400 mg/kg
Administration: P.o.
Result: Decreased neurological deficit scores, reduced brain infarct volume and brain water content, inhibited NF-κB activation and reduced HMGB1 expression.
Molecular Weight

492.43

Formula

C23H24O12
CAS No.
SMILES

O=C1C2=C(O)C=C(O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO)C=C2OC(C4=CC(OC)=C(C(OC)=C4)O)=C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tricin 7-O-β-D-glucopyranoside Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tricin 7-O-β-D-glucopyranoside32769-01-0Apoptosisorally activeneuroprotectivep-NF-κBHMGB1p-κB-αSH-SY5Y cellsInhibitorinhibitorinhibit

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