Tricin 7-O-β-D-glucopyranoside
Based on 1 Customer Validation
Tricin 7-O-β-D-glucopyranoside is a potent and orally active neuroprotective agent. Tricin 7-O-β-D-glucopyranoside induces Apoptosis. Tricin 7-O-β-D-glucopyranoside decreases the expression of TNF-α induced phosphor-κB-α, phosphor-NF-κB, HMGB1.
For research use only. We do not sell to patients.
- Purity : 99.23%
- CAS No.: 32769-01-0
- Formula: C23H24O12
- Molecular Weight:492.43
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Tricin 7-O-β-D-glucopyranoside (4-64 µM; 12 h) induces apoptosis in a dose-dependent manner after oxygen-glucose deprivation for 3 h followed by 12 h incubation in SH-SY5Y cells[1].
Tricin 7-O-β-D-glucopyranoside (16, 32 µM; 12 h) decreases the expression of TNF-α (20 ng/ml for 30 min) induced phosphor-κB-α, phosphor-NF-κB, HMGB1 in SH-SY5Y cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SH-SY5Y cells
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Concentration:2, 4, 8, 16, 32, 64 µM
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Incubation Time:12 h
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Result:Induced cell apoptosis after oxygen-glucose deprivation for 3 h followed by 12 h incubation with neurobasal medium with the apoptosis rate of 35.6%.
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Cell Line:SH-SY5Y cells
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Concentration:16, 32 µM
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Incubation Time:12 h
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Result:Blocked TNF-α (20 ng/ml for 30 min) induced IκB-α and NF-κB phosphorylation, and reduced HMGB1 expression.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult male Sprague-Dawley rats[1]
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Dosage:50, 100, 200 and 400 mg/kg
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Administration:P.o.
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Result:Decreased neurological deficit scores, reduced brain infarct volume and brain water content, inhibited NF-κB activation and reduced HMGB1 expression.
Chemical Information
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CAS No. 32769-01-0
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Appearance Solid
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Molecular Weight 492.43
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Formula C23H24O12
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Color Light yellow to yellow
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SMILES
O=C1C2=C(O)C=C(O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO)C=C2OC(C4=CC(OC)=C(C(OC)=C4)O)=C1
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tricin 7-O-β-D-glucopyranoside Related Classifications
HY-N9587 Related Classifications
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