NF-κB-IN-11
Based on 1 publication(s) in Google Scholar
NF-κB-IN-11 (Compound 3i) is a NF-κB inhibitor. NF-κB-IN-11 inhibits TNF-α induced activation of NF-κB pathway, and inhibits nuclear translocation of NF-κB. NF-κB-IN-11 down-regulates the expression levels of phosphor-IKK, IκBα, and NF-κB p65. NF-κB-IN-11 has anti-inflammatory activity, and alleviates dextran sulfate sodium-induced colitis in mice. NF-κB-IN-11 (p.o.) shows a MTD more than 1852 mg/kg in mice acute toxicity assay.
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- Pureté: 98.42%
- CAS No.: 2768833-35-6
- Formule: C19H18O5
- Masse moléculaire:326.34
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) NF-κB-IN-11
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DLD-1 | IC50 |
8.24 μM
Compound: 3i
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Cytotoxicity against human DLD-1 cells assessed as inhibition in cell proliferation
Cytotoxicity against human DLD-1 cells assessed as inhibition in cell proliferation
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[PMID: 37643546] |
| HCT-116 | IC50 |
14.26 μM
Compound: 3i
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Cytotoxicity against human HCT-116 cells assessed as inhibition in cell proliferation
Cytotoxicity against human HCT-116 cells assessed as inhibition in cell proliferation
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[PMID: 37643546] |
| HEK-293T | CC50 |
94.31 μM
Compound: 3i
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Cytotoxicity against TNF-alpha induced HEK293T cells assessed as inhibition of cell growth preincubated for 24 hrs followed by TNFalpha stimulation and measured after 4 hrs by SRB assay
Cytotoxicity against TNF-alpha induced HEK293T cells assessed as inhibition of cell growth preincubated for 24 hrs followed by TNFalpha stimulation and measured after 4 hrs by SRB assay
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[PMID: 37643546] |
| RAW264.7 | CC50 |
12.16 μM
Compound: 3i
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Cytotoxicity against LPS/IFNgamma induced mouse RAW264.7 cells assessed as inhibition of cell growth preincubated for 24 hrs followed by LPS/IFNgamma stimulation and measured after 24 hrs by SRB assay
Cytotoxicity against LPS/IFNgamma induced mouse RAW264.7 cells assessed as inhibition of cell growth preincubated for 24 hrs followed by LPS/IFNgamma stimulation and measured after 24 hrs by SRB assay
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[PMID: 37643546] |
| RAW264.7 | IC50 |
2.66 μM
Compound: 3i
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition in LPS/IFNgamma-induced NO production preincubated for 2 hrs followed by LPS/IFNgamma stimulation and measured after 24 hrs by Griess reagent based assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition in LPS/IFNgamma-induced NO production preincubated for 2 hrs followed by LPS/IFNgamma stimulation and measured after 24 hrs by Griess reagent based assay
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[PMID: 37643546] |
Chemical Information
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CAS No. 2768833-35-6
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Appearance Solid
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Masse moléculaire 326.34
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Formule C19H18O5
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Color Light yellow to yellow
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SMILES
O=C(C1=C(C2OC1CC2C#CC3=CC=C(C)C=C3)C(OC)=O)OC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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J Hepatocell Carcinoma
ARID3A Promotes Tumor Progression by Activating TNF-α/NF-κB Signaling in Dual-Phenotype Hepatocellular Carcinoma. [Abstract]2025 Nov 19:12:2553-2564. PMID: 41287845
Solvant et solubilité
DMSO : ≥ 100 mg/mL (306.43 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0643 mL | 15.3214 mL | 30.6429 mL | 76.6072 mL |
| 5 mM | 0.6129 mL | 3.0643 mL | 6.1286 mL | 15.3214 mL | |
| 10 mM | 0.3064 mL | 1.5321 mL | 3.0643 mL | 7.6607 mL | |
| 15 mM | 0.2043 mL | 1.0214 mL | 2.0429 mL | 5.1071 mL | |
| 20 mM | 0.1532 mL | 0.7661 mL | 1.5321 mL | 3.8304 mL | |
| 25 mM | 0.1226 mL | 0.6129 mL | 1.2257 mL | 3.0643 mL | |
| 30 mM | 0.1021 mL | 0.5107 mL | 1.0214 mL | 2.5536 mL | |
| 40 mM | 0.0766 mL | 0.3830 mL | 0.7661 mL | 1.9152 mL | |
| 50 mM | 0.0613 mL | 0.3064 mL | 0.6129 mL | 1.5321 mL | |
| 60 mM | 0.0511 mL | 0.2554 mL | 0.5107 mL | 1.2768 mL | |
| 80 mM | 0.0383 mL | 0.1915 mL | 0.3830 mL | 0.9576 mL | |
| 100 mM | 0.0306 mL | 0.1532 mL | 0.3064 mL | 0.7661 mL |
NF-κB-IN-11 Related Classifications
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