2768833-35-6
Chemical Structure
NF-κB-IN-11
- CAS No.: 2768833-35-6
- Formula:C19H18O5
- Molecular Weight:326.34
InChIKey: BQPRNEUDRHTCCF-UHFFFAOYSA-N
SMILES: O=C(C1=C(C2OC1CC2C#CC3=CC=C(C)C=C3)C(OC)=O)OC
Biological Activity: NF-κB-IN-11 (Compound 3i) is a NF-κB inhibitor. NF-κB-IN-11 inhibits TNF-α induced activation of NF-κB pathway, and inhibits nuclear translocation of NF-κB. NF-κB-IN-11 down-regulates the expression levels of phosphor-IKK, IκBα, and NF-κB p65. NF-κB-IN-11 has anti-inflammatory activity, and alleviates dextran sulfate sodium-induced colitis in mice. NF-κB-IN-11 (p.o.) shows a MTD more than 1852 mg/kg in mice acute toxicity assay[1].
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NF-κB-IN-11 | 98.42% | NF-κB-IN-11 (Compound 3i) is a NF-κB inhibitor. NF-κB-IN-11 inhibits TNF-α induced activation of NF-κB pathway, and inhibits nuclear translocation of NF-κB. NF-κB-IN-11 down-regulates the expression levels of phosphor-IKK, IκBα, and NF-κB p65. NF-κB-IN-11 has anti-inflammatory activity, and alleviates dextran sulfate sodium-induced colitis in mice. NF-κB-IN-11 (p.o.) shows a MTD more than 1852 mg/kg in mice acute toxicity assay. | ||||||||||||||||||||
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