2. Apoptosis Immunology/Inflammation Membrane Transporter/Ion Channel
  3. TNF Receptor Interleukin Related Potassium Channel
  4. Immuno modulator-1

Immuno modulator-1 (compound 22) inhibits TNFα and IL-2 secretion in human peripheral blood mononuclear cells (hPBMC), with IC50 values of 4.7 and 26 nM, respectively. Immuno modulator-1 shows hERG potassium channel blocking effect, with Inhibitory percentage of 20% at 3 μM.

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Immuno modulator-1 Chemical Structure

Immuno modulator-1 Chemical Structure

CAS No. : 2757469-20-6

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Immuno modulator-1 Related Antibodies

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Description

Immuno modulator-1 (compound 22) inhibits TNFα and IL-2 secretion in human peripheral blood mononuclear cells (hPBMC), with IC50 values of 4.7 and 26 nM, respectively. Immuno modulator-1 shows hERG potassium channel blocking effect, with Inhibitory percentage of 20% at 3 μM[1].

IC50 & Target

IL-2

 

In Vitro

Immuno modulator-1 (compound 22) inhibits the proliferation of NCI-H929 human myeloma cell, with an IC50 of 0.6 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immuno modulator-1 Related Antibodies
In Vivo

Immuno modulator-1 (compound 22) (1 mg/kg (IV), 5 mg/kg (PO); once) has an oral bioavailability of 30% in Male Sprague-Dawley rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[1]
Dosage: 1 mg/kg (IV), 5 mg/kg (PO)
Administration: IV (2 mL/kg), PO (10 mL/kg); once (Pharmacokinetic Analysis)
Result: Pharmacokinetic Parameters of Immuno modulator-1 in male Sprague-Dawley rats[1].
IV (1 mg/kg) PO (5 mg/kg)
Cmax (ng/mL) 1437
AUC0-24 (ng/mL∗h) 13029
CL (mL/min/kg) 2.2
Vss (L/kg) 0.36
F (%) 30%
Molecular Weight

582.62

Formula

C32H31FN6O4
CAS No.
SMILES

C[C@@H](N1CCN(C2=C(C=C(C=N2)C#N)F)CC1)C(C=C3)=CC=C3COC4=C5C(C(N([C@@H]6C(NC(CC6)=O)=O)C5)=O)=CC=C4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Immuno modulator-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Immuno modulator-12757469-20-6Immuno modulator1Immuno modulator 1TNF ReceptorInterleukin RelatedPotassium ChannelTumor Necrosis Factor ReceptorTNFRILKcsAhPBMCNCI-H929myeloma cellperipheral blood mononuclear cellsInhibitorinhibitorinhibit

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