RJG-2036
RJG-2036 is a potent covalent inhibitor of human prostaglandin reductase 2 (PTGR2)(IC50=100 nM). RJG-2036 inhibits NADPH-dependent reduction, significantly reducing secretion of proinflammatory cytokines like TNF-α and multiple eicosanoids in LPS-stimulated THP-1 macrophages. RJG-2036 is promising for research of inflammatory diseases.
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- CAS No.: 2851993-73-0
- Formule: C20H21N5O4S
- Masse moléculaire:427.48
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Chemical Information
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CAS No. 2851993-73-0
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Masse moléculaire 427.48
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Formule C20H21N5O4S
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SMILES
O=C(N1CCN(CC1)C2=C(OC)C=CC=C2)C3=CC=CC(S(=O)(N4N=CN=C4)=O)=C3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RJG-2036 Related Classifications
HY-174144 Related Classifications
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