2851993-73-0
2851993-73-0
Chemical Structure
RJG-2036
- CAS No.: 2851993-73-0
- Formula:C20H21N5O4S
- Molecular Weight:427.48
SMILES: O=C(N1CCN(CC1)C2=C(OC)C=CC=C2)C3=CC=CC(S(=O)(N4N=CN=C4)=O)=C3
Biological Activity: RJG-2036 is a potent covalent inhibitor of human prostaglandin reductase 2 (PTGR2)(IC50=100 nM). RJG-2036 inhibits NADPH-dependent reduction, significantly reducing secretion of proinflammatory cytokines like TNF-α and multiple eicosanoids in LPS-stimulated THP-1 macrophages. RJG-2036 is promising for research of inflammatory diseases[1].
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RJG-2036 | RJG-2036 is a potent covalent inhibitor of human prostaglandin reductase 2 (PTGR2)(IC50=100 nM). RJG-2036 inhibits NADPH-dependent reduction, significantly reducing secretion of proinflammatory cytokines like TNF-α and multiple eicosanoids in LPS-stimulated THP-1 macrophages. RJG-2036 is promising for research of inflammatory diseases. | |||||||||||||||||||||
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References
Keywords
