IDO1-IN-27
IDO1-IN-27 (Compound I-1) is a Indoleamine 2,3-Dioxygenase 1 (IDO1) inhibitor with an IC50 of 0.3951 μM for recombinant hIDO1. IDO1-IN-27 also inhibits hIDO1 expression in HeLa cells (EC50: 62 nM). IDO1-IN-27 effectively stimulates T cell proliferation by reducing the mRNA expression of pro-inflammatory factors (TNF-α, IL-6, and IL-1β) while concurrently inhibiting LLC cells growth.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C17H16BrFN6O2
- Peso molecular:435.25
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Pureza y Documentación
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Help & FAQs
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Actividad biológica
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hIDO1 0.3951 μM (IC50) |
IL-6 |
IL-1β |
Chemical Information
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Peso molecular 435.25
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Fòrmula C17H16BrFN6O2
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SMILES
O/N=C(C1=NON=C1NCCNC2=CC=CC=C2)\NC3=CC=C(F)C(Br)=C3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IDO1-IN-27 Related Classifications
HY-175182 Related Classifications
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