IDO1-IN-27
IDO1-IN-27 (Compound I-1) is a Indoleamine 2,3-Dioxygenase 1 (IDO1) inhibitor with an IC50 of 0.3951 μM for recombinant hIDO1. IDO1-IN-27 also inhibits hIDO1 expression in HeLa cells (EC50: 62 nM). IDO1-IN-27 effectively stimulates T cell proliferation by reducing the mRNA expression of pro-inflammatory factors (TNF-α, IL-6, and IL-1β) while concurrently inhibiting LLC cells growth.
For research use only. We do not sell to patients.
- Formula: C17H16BrFN6O2
- Molecular Weight:435.25
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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hIDO1 0.3951 μM (IC50) |
IL-6 |
IL-1β |
Chemical Information
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Molecular Weight 435.25
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Formula C17H16BrFN6O2
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SMILES
O/N=C(C1=NON=C1NCCNC2=CC=CC=C2)\NC3=CC=C(F)C(Br)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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