TLR8 agonist 7
TLR8 agonist 7 (Compound II-36) is an agonist for Toll-like receptor 8 (TLR8) with EC50 <250 nM. TLR8 agonist 7 is stable in human and murine plasma, induces secretion of cytokines TNFα, with EC50 <1 μM. TLR8 agonist 7 exhibits antitumor activity in MC38-HER2 xenograft mouse model with a tumor growth inhibition (TGI) rate of 98%.
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- CAS No.: 3034750-26-7
- Formula: C54H63N9O16
- Molecular Weight:1094.13
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Biological Activity
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TLR8 |
Chemical Information
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CAS No. 3034750-26-7
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Molecular Weight 1094.13
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Formula C54H63N9O16
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SMILES
O[C@H]([C@@H](C(O)=O)O1)[C@H](O)[C@@H](O)[C@@H]1OC2=C(NC(CNC(CCCCCN3C(C=CC3=O)=O)=O)=O)C=C(COC(N4CC5=CC(NC(C6(CC6)C7=CC=C8C(N=C(N)CC(C(N(CCC)CCO)=O)=C8)=C7)=O)=CN=C5CC4)=O)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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