3034750-26-7
Chemical Structure
TLR8 agonist 7
- CAS 番号: 3034750-26-7
- Formula:C54H63N9O16
- Molecular Weight:1094.13
InChIKey: GJFXEIGDVDYWLG-HHEFPRIFSA-N
SMILES: O[C@H]([C@@H](C(O)=O)O1)[C@H](O)[C@@H](O)[C@@H]1OC2=C(NC(CNC(CCCCCN3C(C=CC3=O)=O)=O)=O)C=C(COC(N4CC5=CC(NC(C6(CC6)C7=CC=C8C(N=C(N)CC(C(N(CCC)CCO)=O)=C8)=C7)=O)=CN=C5CC4)=O)C=C2
Biological Activity: TLR8 agonist 7 (Compound II-36) is an agonist for Toll-like receptor 8 (TLR8) with EC50 <250 nM. TLR8 agonist 7 is stable in human and murine plasma, induces secretion of cytokines TNFα, with EC50 <1 μM. TLR8 agonist 7 exhibits antitumor activity in MC38-HER2 xenograft mouse model with a tumor growth inhibition (TGI) rate of 98%[1].
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TLR8 agonist 7 | TLR8 agonist 7 (Compound II-36) is an agonist for Toll-like receptor 8 (TLR8) with EC50 <250 nM. TLR8 agonist 7 is stable in human and murine plasma, induces secretion of cytokines TNFα, with EC50 <1 μM. TLR8 agonist 7 exhibits antitumor activity in MC38-HER2 xenograft mouse model with a tumor growth inhibition (TGI) rate of 98%. | |||||||||||||||||||||
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