CHNQD-03005
CHNQD-03005 is an orally active anti-inflammatory agent. CHNQD-03005 inhibits the expression of iNOS and COX-2, reduces inflammatory signal transduction, suppresses NO production, and downregulates the pro-inflammatory cytokines TNF-α, IL-6 and IL-1β. CHNQD-03005 can be used in the research of inflammatory diseases such as colitis.
For research use only. We do not sell to patients.
- Formula: C31H28O7
- Molecular Weight:512.55
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
IL-6 |
COX-2 |
IL-1β |
CHNQD-03005 (Compound C13) (24 h) inhibits the production of TNF-α, IL-1β, IL-6 and NO in LPS (HY-D1056)-stimulated RAW264.7 cells, with IC50 values of 0.45 μM, 0.086 μM, 0.095 μM, and 0.038 μM, respectively[1].
CHNQD-03005 (0.2-6 μM) inhibits the protein expression of iNOS, COX-2 and IL-1β in LPS (HY-D1056)-stimulated RAW264.7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:LPS (HY-D1056)-stimulated RAW264.7 cells
-
Concentration:0.2, 2 and
-
Incubation Time:6 μM
-
Result:Inhibited the protein expression of iNOS, COX-2, and IL-1β in a concentration-dependent manner.
CHNQD-03005 (100 mg/kg; p.o.; single administration) exhibits favorable safety, with an oral MTD exceeding 100 mg/kg in male C57BL/6J mice[1].
CHNQD-03005 (20 mg/kg; p.o.; 21 days) is well tolerated in ICR mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:C57BL/6J (male, 8 weeks old) treated DSS (HY-116282C)[1]
-
Dosage:1 mg/kg
-
Administration:p.o.; daily; 7-9 days
-
Result:Significantly improved body weight loss, DAI scores, and colon length.
Preserved intestinal mucosal integrity, reduced crypt loss and inflammatory infiltration, and restored colonic architecture.
Reduced colon levels of TNF-α and IL-1β to control levels.
Chemical Information
-
Molecular Weight 512.55
-
Formula C31H28O7
-
SMILES
C=CCOC1=CC=C(C=C1)C2=CC(OC)=C(C(OCC=C)=C2OC)C3=CC=C(C=C3)OC(C4=CC=CO4)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz