5-LOX-IN-8
5-LOX-IN-8 is a 5-LOX inhibitor with anti-inflammatory activity. 5-LOX-IN-8 suppresses IL-6, IL-1β, TNF-α and IFN-γ in macrophages and reduces IL-8 secretion in SW480 cells. 5-LOX-IN-8 reduces disease activity in a DSS colitis model. 5-LOX-IN-8 can be used for research of inflammatory bowel disease (IBD).
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- Formule: C29H34O6
- Masse moléculaire:478.58
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
[1]|
5-LOX |
IL-6 |
IL-1β |
IL-8 |
In Vitro
5-LOX-IN-8 (Compound 18d) (0.3-50 μM, 24 h) shows cytotoxicity in THP-1 cell (IC50: 37.65 μM) and SW 480 cell (IC50: 14.37 μM)[1].
5-LOX-IN-8 (10 μM, 5 min) inhibits human recombinant 5-LOX by 40.65%, and also inhibits NO production by 38.85% in SW480 cells[1].
5-LOX-IN-8 (10 μM, 1 h pretreatment and 24 h co-culture with LPS) suppresses IL-6 (93.98%), IL-1β (19.41%), TNF-α (45.97%) and IFN-γ (66.61%) production in LPS (HY-D1056)-stimulated THP-1 macrophages[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:THP-1 cell, SW 480 cell
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Concentration:0.3-50 μM
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Incubation Time:24 h
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Result:Inhibited the cell viability of THP-1 cell (IC50: 37.65 μM) and SW 480 cell (IC50: 14.37 μM).
And the cell viability of THP-1 cell and SW 480 cell at 50 μM were 65.54% and 56.23%, respectively.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:5% DSS (v/v, in drinking water, every second day) murine colitis model
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Dosage:30 mg/kg
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Administration:
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Result:Increased the body weight (87.84%) compared with DSS-treated group (73.75%).
Slightly increased the colon length (mm) compared with DSS-treated group.
Significantly reduced DAI from Day-4 to Day-7, with a Day-7 DAI of 8.67 compared to 11.67 for the DSS-treated group.
Chemical Information
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Masse moléculaire 478.58
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Formule C29H34O6
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SMILES
COC1=C(OC)C(OC)=CC(CC2(CC3=CC(OC)=C(OC)C(OC)=C3)CC4=C(C=CC=C4)C2)=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
5-LOX-IN-8 Related Classifications
HY-173180 Related Classifications
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