Troponin-IN-1
Troponin-IN-1 is a troponin inhibitor. Troponin-IN-1 protects OGD/R-injured H9c2 cardiomyocytes by reducing LDH leakage, pyroptosis and ROS accumulation. Troponin-IN-1 inhibits NO production and IL-1β/TNF-α/IL-18 release in LPS (HY-D1056)-induced RAW264.7 cells. Troponin-IN-1 acts via caspase-1/GSDMD/IL-18 pathway. Troponin-IN-1 reduces myocardial infarct size in LAD-induced myocardial ischemia/reperfusion (MI/R) male rats. Troponin-IN-1 can be used for the study of myocardial ischemia/reperfusion (MI/R) injury.
For research use only. We do not sell to patients.
- Formula: C22H30O5
- Molecular Weight:374.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
Troponin-IN-1 (Compound 19) (0.1-10 μM, 24 h) enhances viability of OGD/R-injured H9c2 cardiomyocytes , reduces LDH leakage and inhibits ROS accumulation[1].
Troponin-IN-1 (10-50 μM) decreases pyroptotic H9c2 cells, maintains cell morphology and blocks pyroptosis by inhibiting caspase-1/GSDMD/IL-18 pathway[1].
Troponin-IN-1 (6.25-100 μM, pretreatment for 30 min) inhibits NO production in LPS (HY-D1056)-induced RAW264.7 cells (IC50 = 13.49 μM) and reduces IL-1β, TNF-α, IL-18 release[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LPS (HY-D1056)-induced RAW264.7 cells
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Concentration:10, 30, 50 μM
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Incubation Time:Pretreatment for 30 min
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Result:Reduced IL-1β, TNF-α, IL-18 release.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley rats: chest opened between 3rd and 4th ribs, left anterior descending coronary artery (LAD) ligated for 45 min, then ligature loosened for 24 h reperfusion to establish myocardial ischemia/reperfusion (MI/R) model[1]
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Dosage:20, 40, 80 mg/kg
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Administration:intraperitoneal injection, once daily for 7 days, last dose 1 h before surgery
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Result:Reduced myocardial infarct size.
Decreased serum cTn1 level, increased serum SOD activity.
Decreased serum MDA content.
Alleviated myocardial cell necrosis and inflammatory infiltration.
Showed no significant changes in body weight.
Chemical Information
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Molecular Weight 374.47
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Formula C22H30O5
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SMILES
O=C(O[C@@H]1[C@](C2(C)C)(C)CC[C@@H]2C1)/C=C/C3=CC=C(OC)C(OC)=C3OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Troponin-IN-1 Related Classifications
HY-175640 Related Classifications
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