1-(2,5-Dihydroxyphenyl)-3-hydroxybutan-1-one
1-(2,5-Dihydroxyphenyl)-3-hydroxybutan-1-one is an inhibitor of iNOS and COX-2. 1-(2,5-Dihydroxyphenyl)-3-hydroxybutan-1-one inhibits LPS-induced excessive production of NO and PGE2, as well as the mRNA expression of pro-inflammatory cytokines TNF-α, IL-1β, IL-6 and IL-12. 1-(2,5-Dihydroxyphenyl)-3-hydroxybutan-1-one can be used in inflammation-related research.
For research use only. We do not sell to patients.
- CAS No.: 1083202-40-7
- Formula: C10H12O4
- Molecular Weight:196.20
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
COX-2 |
iNOS |
TNF-α 12.5 μM (IC50) |
IL-1β 11.7 μM (IC50) |
IL-6 10.6 μM (IC50) |
IL-12 13.5 μM (IC50) |
In Vitro
1-(2,5-Dihydroxyphenyl)-3-hydroxybutan-1-one (compound 7) (2.5-20.0 μM; 12 h pretreatment followed by 18 h LPS co-treatment) inhibits LPS-induced nitrite production in RAW264.7 macrophages with an IC50 of 12.5 μM, and suppresses PGE2 production with an IC50 of 9.5 μM[1].
1-(2,5-Dihydroxyphenyl)-3-hydroxybutan-1-one (2.5-20.0 μM; 12 h pretreatment followed by 18 h LPS co-treatment) dose-dependently inhibits LPS-induced iNOS and COX-2 protein expression in RAW264.7 macrophages[1].
1-(2,5-Dihydroxyphenyl)-3-hydroxybutan-1-one (pretreated for 12 h, followed by co-treatment with LPS for 18 h) inhibits LPS-induced mRNA expression of TNF-α, IL-1β, IL-6 and IL-12 in RAW264.7 macrophages, with IC50 values of 12.5, 11.7, 10.6 and 13.5 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW264.7 macrophages
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Concentration:2.5, 5, 10, 20 μM
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Incubation Time:12 h pretreatment, followed by 18 h LPS co-treatment
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Result:Attenuated LPS-induced iNOS and COX-2 protein expression in a dose-dependent manner.
Chemical Information
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CAS No. 1083202-40-7
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Molecular Weight 196.20
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Formula C10H12O4
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SMILES
OC1=CC=C(C=C1C(CC(C)O)=O)O
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Structure Classification
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Initial Source
Paraconiothyrium sp
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
1-(2,5-Dihydroxyphenyl)-3-hydroxybutan-1-one Related Classifications
HY-N19110 Related Classifications
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