Lansiumamide B
Lansiumamide B is a cinnamamide alkaloid, Antifungal agent and Insecticide. Lansiumamide B is isolated from the seeds of Clausena lansium. Lansiumamide B inhibits the phosphorylation of p38 MAPK, and decreases the protein and mRNA levels of TNF-α. Lansiumamide B induces abnormal mycelial growth, cell content leakage and cell wall degradation in Rhizoctonia solani. Lansiumamide B causes the death of early 4th-instar larvae of Aedes albopictus. Lansiumamide B exhibits anticonvulsant effects in epileptic rat models. Lansiumamide B can be used in studies related to plant fungal diseases.
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- CAS. Nr.: 121817-37-6
- Formel: C18H17NO
- Molecular Weight:263.33
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Lansiumamide B (100 μg/mL; 3-5 days) exhibits broad-spectrum in vitro antifungal activity against phytopathogenic fungi, acting against 10 species of phytopathogenic fungi, with the strongest activity against Rhizoctonia solani (EC50 = 2.99 μg/mL) and Botrytis cinerea (EC50 = 4.31 μg/mL)[1].
Lansiumamide B (100 µg/mL) potently inhibits the in vitro growth of 10 phytopathogenic fungi, with the highest inhibition rate (91.20%) against Thanatephorus cucumeris[3].
Lansiumamide B (5 μg/mL; 12 h) alters the transcriptome of Rhizoctonia solani, significantly upregulates genes related to polysaccharide hydrolysis, and enriches pathways associated with starch, sucrose and galactose metabolism. The transcriptome results are validated by qRT-PCR[1].
Lansiumamide B (5-50 μM; 30 min) dose-dependently inhibits histamine release from A23187-stimulated RBL-2H3 cells, reducing histamine release to 71.2% of that in the control group at 50 μM, with no cytotoxicity observed at this concentration[2].
Lansiumamide B (5-50 μM; 30 min) significantly reduces TNF-α secretion in A23187-stimulated RBL-2H3 cells, reaching only 47.5% of the control level at 50 μM, but exerts no significant inhibitory effect on COX-2 protein expression at concentrations up to 50 μM[2].
Lansiumamide B (5-50 μM; 30 min) does not significantly reduce the mRNA levels of COX-2, TNF-α or IL-6 in A23187-stimulated RBL-2H3 cells even at concentrations as high as 50 μM[2].
Lansiumamide B (5-50 μM; 30 min) reduces the level of phosphorylated p38 MAPK by 41.8% in A23187-stimulated RBL-2H3 cells at the concentration of 50 μM, but does not significantly alter the phosphorylation levels of PKCθ, IκBα or p65 NFκB even at the highest concentration of 50 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A23187-stimulated RBL-2H3 cells
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Concentration:5-50 μM
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Incubation Time:30 min pre-incubation, then 3 h stimulation
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Result:Subtly reduced COX-2, TNF-α, and IL-6 mRNA levels compared to A23187-stimulated controls, but none of these reductions were statistically significant.
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Cell Line:A23187-stimulated RBL-2H3 cells
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Concentration:5-50 μM
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Incubation Time:30 min pre-incubation, then 15 min stimulation
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Result:Caused a slight, non-statistically significant reduction in phosphorylated PKCθ relative intensity at 5 μM.
Reduced the relative intensity of phosphorylated p38 MAPK by 41.8% compared to A23187-stimulated controls at 50 μM, but this reduction was not statistically significant.
Had virtually no effect on the phosphorylation of IκBα or p65 NFκB.
Lansiumamide B (200-800 μg/mL; sprayed on both adaxial and abaxial leaf surfaces) exhibits concentration-dependent protective and curative effects against Botrytis cinerea on strawberry leaves[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:40-day-old plants[1]
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Dosage:200 μg/mL; 400 μg/mL; 800 μg/mL
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Administration:sprayed on adaxial and abaxial leaf surfaces
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Result:Showed 19.04% protective efficacy and 12.31% curative efficacy against Rhizoctonia solani at 200 μg/mL.
Showed 27.21% protective efficacy and 33.33% curative efficacy against Rhizoctonia solani at 400 μg/mL.
Reached 53.06% protective efficacy and 71.01% curative efficacy against Rhizoctonia solani at 800 μg/mL.
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Animal Model:40-day-old plants[1]
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Dosage:200 μg/mL; 400 μg/mL; 800 μg/mL
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Administration:sprayed on adaxial and abaxial leaf surfaces
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Result:Showed 7.09% protective efficacy and 31.37% curative efficacy against Botrytis cinerea at 200 μg/mL.
Showed 41.54% protective efficacy and 48.82% curative efficacy against Botrytis cinerea at 400 μg/mL.
Reached 61.39% protective efficacy and 67.95% curative efficacy against Botrytis cinerea at 800 μg/mL.
Chemical Information
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CAS. Nr. 121817-37-6
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Molecular Weight 263.33
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Formel C18H17NO
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SMILES
CN(/C=C\C1=CC=CC=C1)C(/C=C/C2=CC=CC=C2)=O
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[2]. Matsui T, et al. Lansiumamide B and SB-204900 isolated from Clausena lansium inhibit histamine and TNF-α release from RBL-2H3 cells. Inflamm Res. 2013 Mar;62(3):333-41. [Content Brief]
[3]. Xu H, et al. Synthesis and Fungicidal Activity of Lansiumamide A and B and Their Derivatives. Molecules (Basel, Switzerland). 2018 Jun 21;23(7):1499. [Content Brief]
[4]. Han Y, et al. Larvicidal activity of lansiumamide B from the seeds of Clausena lansium against Aedes albopictus (Diptera: Culicidae). Parasitology research. 2013 Feb;112(2):511-6. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Lansiumamide B Related Classifications
HY-N20748 Related Classifications
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