HSP90-IN-31
HSP90-IN-31 (compound Be01) causes reduction of CD80 and CD86 expression on dendritic cells (DCs). HSP90-IN-31 decreases the production of pro-inflammatory cytokines (IL-6, TNF-α, and IL-1β) in BMDC and peritoneal macrophages stimulated by LPS (HY-D1056). Under the delayed-type hypersensitivity (DTH) mice model, HSP90-IN-31 reduces ear swelling and pro-inflammatory cytokines in the spleen.
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- CAS. Nr.: 2117645-10-8
- Formel: C22H28N2O4
- Molecular Weight:384.47
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Biologische Aktivität
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IL-6 |
IL-1β |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NCI-H1975 | GI50 |
0.42 μM
Compound: 30f
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Antiproliferative activity against human NCI-H1975 cells after 72 hrs by Cell Titer 96 Aqueous One Solution cell proliferation assay
Antiproliferative activity against human NCI-H1975 cells after 72 hrs by Cell Titer 96 Aqueous One Solution cell proliferation assay
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[PMID: 29202402] |
Chemical Information
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CAS. Nr. 2117645-10-8
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Molecular Weight 384.47
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Formel C22H28N2O4
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SMILES
CC(C)C1=C(O)C=C(O)C(C(N(C)CC2=CC=C(C(NCCC)=O)C=C2)=O)=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
HSP90-IN-31 Related Classifications
HY-161833 Related Classifications
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