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Cat. No.: HY-N16066

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Candidusin A

(Synonyms: CHNQD-0803)

Candidusin A (CHNQD-0803) (Compound 4) is a AMPK activator with a K_D of 47.28 nM. Candidusin A can be isolated from marine fungus Aspergillus candidus. Candidusin A has cytotoxic activity and induces apoptosis in human prostate cancer cells (22Rv1, PC-3 and LNCaP cells). Candidusin A reduces adipogenesis genes expression and fat deposition, negatively regulates the NF-κB-TNFα inflammatory axis to suppress inflammation, and ameliorates liver injury and fibrosis. Candidusin A can be used for non-alcoholic steatohepatitis (NASH) research.

For research use only. We do not sell to patients.

CAS No.: 81474-59-1
Formula: C₂₀H₁₆O₆
Molecular Weight:352.34

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Candidusin A Chemical Structure

CAS No.: 81474-59-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All AMPK Isoforms :

All NF-κB Isoforms :

All TNF Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	19.34 μM Compound: 14	Cytotoxicity against human A549 cells by SRB assay Cytotoxicity against human A549 cells by SRB assay	[PMID: 21486068]
HL-60	IC₅₀	77.56 μM Compound: 14	Cytotoxicity against human HL60 cells by MTT assay Cytotoxicity against human HL60 cells by MTT assay	[PMID: 21486068]
P388	IC₅₀	46.83 μM Compound: 14	Cytotoxicity against mouse P388 cells by MTT assay Cytotoxicity against mouse P388 cells by MTT assay	[PMID: 21486068]

Chemical Information

CAS No. 81474-59-1
Molecular Weight 352.34
Formula C₂₀H₁₆O₆
SMILES

OC1=CC=C(C2=CC(OC)=C3C(OC4=CC(O)=C(C=C43)O)=C2OC)C=C1
Synonyms

CHNQD-0803
Structure Classification
- Phenols
- Monophenols
Initial Source
- Microorganisms
Aspergillus candidus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yurchenko A N, et al. Metabolites of the marine fungus Aspergillus candidus KMM 4676 associated with a kuril colonial ascidian[J]. Chemistry of Natural Compounds, 2017, 53(4): 747-749.

[2]. Chen J, et al. Discovery of a natural small-molecule AMP-activated kinase activator that alleviates nonalcoholic steatohepatitis. Mar Life Sci Technol. 2023 Apr 30;5(2):196-210. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
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References

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Candidusin A

All AMPK Isoforms

All NF-κB Isoforms

All TNF Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Candidusin A Related Classifications

HY-N16066 Related Classifications