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Cat. No.: HY-W001288S

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Indole-4-carboxaldehyde-¹³C

Indole-4-carboxaldehyde-¹³C is the ¹³C-labeled Indole-4-carboxaldehyde (HY-W001288). Indole-4-carboxaldehyde is an ergot alkaloid precursor. Indole-4-carboxaldehyde attenuates the methylglyoxal (MGO)-induced expression of inflammatory-related genes, such asTNF-α and IFN-γ by activating NF-κB without toxicity in HepG2 cells. Indole-4-carboxaldehyde reduces the MGO-induced AGE formation and the expression of the receptor for AGE (RAGE). Indole-4-carboxaldehyde can be used for the study of hepatic steatosis.

For research use only. We do not sell to patients.

Formula: C₈¹³CH₇NO
Molecular Weight:146.15

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Indole-4-carboxaldehyde-¹³C Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Application
Chemical Information
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

All NF-κB Isoforms :

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled Cas 1074-86-8
Molecular Weight 146.15
Formula C₈¹³CH₇NO
SMILES

O=[13CH]C1=C2C(NC=C2)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cha SH, et al. Indole-4-carboxaldehyde Isolated from Seaweed, Sargassum thunbergii, Attenuates Methylglyoxal-Induced Hepatic Inflammation. Mar Drugs. 2019 Aug 21;17(9):486. [Content Brief]

[2]. Alan P. Kozikowski, et al. New synthesis and some selected reactions of the potential ergot alkaloid precursor indole-4-carboxaldehyde. J. Org. Chem. 1980, 45, 16, 3350-3352.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- In Vitro
- Application
Chemical Information
Purity & Documentation
References

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Indole-4-carboxaldehyde-13C

All NF-κB Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Indole-4-carboxaldehyde-13C Related Classifications

HY-W001288S Related Classifications

Indole-4-carboxaldehyde-¹³C

Indole-4-carboxaldehyde-¹³C Related Classifications