1074-86-8
1074-86-8
Chemical Structure
Indole-4-carboxaldehyde
- CAS No.: 1074-86-8
- Formula:C9H7NO
- Molecular Weight:145.16
IUPAC Name: 1H-indole-4-carbaldehyde
InChIKey: JFDDFGLNZWNJTK-UHFFFAOYSA-N
SMILES: O=CC1=CC=CC2=C1C=CN2
Biological Activity: Indole-4-carboxaldehyde is an ergot alkaloid precursor. Indole-4-carboxaldehyde attenuates the methylglyoxal (MGO)-induced expression of inflammatory-related genes, such asTNF-α and IFN-γ by activating NF-κB without toxicity in HepG2 cells. Indole-4-carboxaldehyde reduces the MGO-induced AGE formation and the expression of the receptor for AGE (RAGE). Indole-4-carboxaldehyde can be used for the study of hepatic steatosis[1][2].
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Indole-4-carboxaldehyde | 99.32% | Indole-4-carboxaldehyde is an ergot alkaloid precursor. Indole-4-carboxaldehyde attenuates the methylglyoxal (MGO)-induced expression of inflammatory-related genes, such asTNF-α and IFN-γ by activating NF-κB without toxicity in HepG2 cells. Indole-4-carboxaldehyde reduces the MGO-induced AGE formation and the expression of the receptor for AGE (RAGE). Indole-4-carboxaldehyde can be used for the study of hepatic steatosis. | ||||||||||||||||||||
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Indole-4-carboxaldehyde-13C | Indole-4-carboxaldehyde-13C is the 13C-labeled Indole-4-carboxaldehyde (HY-W001288). Indole-4-carboxaldehyde is an ergot alkaloid precursor. Indole-4-carboxaldehyde attenuates the methylglyoxal (MGO)-induced expression of inflammatory-related genes, such asTNF-α and IFN-γ by activating NF-κB without toxicity in HepG2 cells. Indole-4-carboxaldehyde reduces the MGO-induced AGE formation and the expression of the receptor for AGE (RAGE). Indole-4-carboxaldehyde can be used for the study of hepatic steatosis. | |||||||||||||||||||||
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References
- [1]. Cha SH, et al. Indole-4-carboxaldehyde Isolated from Seaweed, Sargassum thunbergii, Attenuates Methylglyoxal-Induced Hepatic Inflammation. Mar Drugs. 2019 Aug 21;17(9):486. [Content Brief]
- [2]. Alan P. Kozikowski, et al. New synthesis and some selected reactions of the potential ergot alkaloid precursor indole-4-carboxaldehyde. J. Org. Chem. 1980, 45, 16, 3350-3352.
