Betamethasone succinate
Betamethasone succinate (NSSL-BMS) is a nano-formulation that can cross the blood-brain barrier. Betamethasone succinate is prepared by encapsulating the Betamethasone (HY-13570) semi-succinate in PEG-liposomes. Betamethasone succinate utilizes the enhanced permeation and retention effects of liposomes to target and deliver the potent glucocorticoid to the inflammatory sites. Betamethasone succinate inhibits the secretion of pro-inflammatory cytokines (such as TNF-α and IL-6) while maintaining the level of anti-inflammatory cytokine TGF-β. Betamethasone succinate can be used in the research of arthritis and cerebral malaria.
For research use only. We do not sell to patients.
- CAS No.: 27297-42-3
- Formula: C26H33FO8
- Molecular Weight:492.53
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
IL-6 |
Chemical Information
-
CAS No. 27297-42-3
-
Molecular Weight 492.53
-
Formula C26H33FO8
-
SMILES
C[C@@]12[C@](C[C@@H]([C@]2(O)C(COC(CCC(O)=O)=O)=O)C)([H])[C@@]3([H])[C@]([C@H](C1)O)([C@@]4(C(CC3)=CC(C=C4)=O)C)F
-
Synonyms
NSSL-BMS
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Ulmansky R, et al. Glucocorticoids in nano-liposomes administered intravenously and subcutaneously to adjuvant arthritis rats are superior to the free drugs in suppressing arthritis and inflammatory cytokines. J Control Release. 2012 Jun 10;160(2):299-305. [Content Brief]
[2]. Waknine-Grinberg JH, et al. Glucocorticosteroids in nano-sterically stabilized liposomes are efficacious for elimination of the acute symptoms of experimental cerebral malaria. PLoS One. 2013 Aug 26;8(8):e72722. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz