Palmitoyl tripeptide-8
Palmitoyl tripeptide-8 is an immunomodulatory peptide and neurotransmitter inhibitory peptide. Palmitoyl tripeptide-8 inhibits the activation of the NF-κB pathway and the production of pro-inflammatory cytokines (IL-8, IL-6, and TNF-α). Palmitoyl tripeptide-8 activates the cutaneous opioid system and reduces CGRP release. Palmitoyl tripeptide-8 decreases the number of dilated capillaries, the size of dilated vessels, and the degree of edema in skin explants treated with Substance P (HY-P0201). Palmitoyl tripeptide-8 is used as an active ingredient in cosmetics for sensitive skin. Palmitoyl tripeptide-8 is utilized in research related to sensitive skin.
For research use only. We do not sell to patients.
- CAS No.: 936544-53-5
- Formula: C37H61N9O4
- Molecular Weight:695.94
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
[1]|
IL-6 |
IL-8 |
In Vitro
Palmitoyl tripeptide-8 exhibits immunomodulatory activity in skin-related systems by reducing NF-κB activation and suppressing IL-6 and TNF-α production, thereby decreasing inflammation, redness, and skin sensitivity[1].
Palmitoyl tripeptide-8 inhibits IL-8 production in UVB-irradiated keratinocytes by up to 32%[2].
Palmitoyl tripeptide-8 reduces capillary dilation and edema in substance P-exposed skin explants, with 30% reduction in dilated capillary number, 51% reduction in dilated vessel size, and 60% reduction in edema[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 936544-53-5
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Molecular Weight 695.94
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Formula C37H61N9O4
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Sequence
{palmitoyl-His}-{d-Phe}-Arg-NH2
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Sequence Shortening
{palmitoyl-His}-{d-Phe}-R-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Palmitoyl tripeptide-8 Related Classifications
HY-P5226 Related Classifications
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Keywords
- Palmitoyl tripeptide-8
- 936544-53-5
- Palmitoyl tripeptide8
- Palmitoyl tripeptide 8
- NF-κB
- Interleukin Related
- Opioid Receptor
- CGRP Receptor
- TNF Receptor
- NF-κB pathway
- CGRP
- pro-inflammatory cytokine
- substance P-exposed skin explants
- UVB-irradiated keratinocytes
- IL-8
- α-melanocyte stimulating hormone
- IL-1-stimulated fibroblasts
- sodium dodecyl sulfate-induced skin irritation
- cutaneous opioid system
- Inhibitor
- inhibitor
- inhibit