1-(3-Carboxypropyl)-3,7-dimethylxanthine

1-(3-Carboxypropyl)-3,7-dimethylxanthine (1 mg/mL; 5 h) weakly inhibits LPS-stimulated TNF-α production in RAW 264.7 murine macrophages, with significant inhibition only at the lower LPS concentration (10 ng/mL) and no effect at 100 ng/mL LPS^[1].
1-(3-Carboxypropyl)-3,7-dimethylxanthine (1 mg/mL; 24 h) significantly protects WC/1 murine fibrosarcoma cells from TNF-α-induced cytotoxicity at a concentration of 1 mg/mL^[1].
1-(3-Carboxypropyl)-3,7-dimethylxanthine (0.5-2 mg/mL; 24 h) does not reduce H5V murine endothelioma cell viability at concentrations ranging from 0.5 to 2 mg/mL over a 24-hour incubation^[1].
1-(3-Carboxypropyl)-3,7-dimethylxanthine (1 mg/mL; 24 h) does not inhibit TNF-α-induced VCAM-1 expression in H5V murine endothelioma cells at a concentration of 1 mg/mL^[1].
1-(3-Carboxypropyl)-3,7-dimethylxanthine (up to 50 μg/mL; 40 min for MDR1, BCRP; 60 min for MRP1) does not interact significantly with human MDR1, MRP1, or BCRP transporters, as indicated by no stimulation of their vanadate-sensitive ATPase activity at concentrations up to 50 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.