1. NF-κB
    Apoptosis
  2. NF-κB
    Apoptosis
  3. Ginsenoside Rg6

Ginsenoside Rg6 

Cat. No.: HY-N0907
Handling Instructions

Ginsenoside Rg6 is the component isolated from notoginseng. Ginsenoside Rg6 inhibits TNF-α-induced NF-κB transcriptional activity with an IC50 of 29.34±2.22 μM in HepG2 cells. Ginsenoside Rg6 also exhibits apoptosis-inducing effect.

For research use only. We do not sell to patients.

Ginsenoside Rg6 Chemical Structure

Ginsenoside Rg6 Chemical Structure

CAS No. : 147419-93-0

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Description

Ginsenoside Rg6 is the component isolated from notoginseng. Ginsenoside Rg6 inhibits TNF-α-induced NF-κB transcriptional activity with an IC50 of 29.34±2.22 μM in HepG2 cells. Ginsenoside Rg6 also exhibits apoptosis-inducing effect.

IC50 & Target[1][2]

NF-κB

25.12 μM (IC50, in SK-Hep1 cell)

NF-κB

29.34 μM (IC50, in HepG2 cell)

Apoptosis

 

In Vitro

Ginsenoside Rg6 inhibits TNF-α-induced NF-κB transcriptional activity with an IC50 of 25.12±1.04 μM in SK-Hep1 cells, consistent with the data from HepG2 cells[1]. Ginsenoside Rg6 exhibits obvious anti-proliferative and apoptosis-inducing effects when it is applied to JK cells in vitro. Ginsenoside Rg6 blocks S arrest in the cell cycle. CCK-8 method shows that after Ginsenoside Rg6 is used, several groups with different concentrations obviously inhibits JK cell proliferation in human lymphocytoma, with evident dose dependency. Based on IC50, the median inhibitory concentration of Ginsenoside Rg6 is 83.08 μM[2].

Molecular Weight

767.00

Formula

C₄₂H₇₀O₁₂

CAS No.

147419-93-0

SMILES
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Cell Assay
[1]

HepG2 and SK-Hep1 cells are maintained in Dulbecco’s modified Eagle’s medium containing 10% heat-inactivated fetal bovine serum, 100 units/mL Penicillin, and 10 μg/mL Streptomycin, at 37°C and 5% CO2. Cell-Counting Kit (CCK)-8is used to analyze the effect of compounds (e.g., Ginsenoside Rg6; 0.01, 0.1, 1 and 10 μM) on cell toxicity. Cells are cultured overnight in 96-well plate (~1×104 cells/well). Cell toxicity is assessed after the addition of compounds on dose-dependent manner. After 24 h of treatment, 10 μL of the CCK-8 solution is added to triplicate wells, and incubated for 1 h. Absorbance is measured at 450 nm to determine viable cell numbers in wells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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Keywords:

Ginsenoside Rg6Ginsenoside Rg 6Ginsenoside Rg-6NF-κBApoptosisNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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