CF-Eugenol
CF-Eugenol (Eugenol-clofibrate) is an orally effective PPAR-α activator. CF-Eugenol drives the expression of lipid-lowering genes and reduces serum triglyceride and total cholesterol in a dose-dependent manner. CF-Eugenol upregulates hepatic Nrf2 expression and activates the Nrf2/HO-1 axis to coordinate the expression of antioxidant and detoxifying enzymes. CF-Eugenol enhances antioxidant defense by increasing SOD activity and GSH content and reducing MDA accumulation. CF-Eugenol downregulates hepatic TNF-α and IL-6 to exert anti-inflammatory effects. CF-Eugenol reduces serum ALT, AST, and AKP and improves liver histopathology. CF-Eugenol can be used for research on hyperlipidemia.
For research use only. We do not sell to patients.
- CAS No.: 1449608-33-6
- Formula: C20H21ClO4
- Molecular Weight:360.83
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
PPAR-α |
IL-6 |
Nrf2 |
SOD |
HO-1 |
TNF-α |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:KM mice, body weight 20 g[1]
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Dosage:0.1335 mmol/kg; 0.267 mmol/kg; 0.534 mmol/kg
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Administration:intragastric administration; daily dosing; 7 consecutive days
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Result:Reduced lipid levels in a dose-dependent manner.
Was more effective than CF in lowering TG levels.
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Animal Model:KM mice, body weight 20 g[1]
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Dosage:1.65 mmol/kg
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Administration:intragastric administration; once daily for 30 consecutive days
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Result:In the CF-Eugenol group, liver weight and the liver-to-body-weight ratio were significantly lower than those in the CF group.
AST, ALT, and AKP levels decreased by 31.56%, 31.56%, and 49.35%, respectively, indicating a significant reduction in liver injury.
Oxidative stress was notably alleviated, as evidenced by increased SOD activity, elevated GSH content, and reduced MDA levels.
Chemical Information
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CAS No. 1449608-33-6
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Molecular Weight 360.83
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Formula C20H21ClO4
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SMILES
C=CCC1=CC=C(C(OC)=C1)OC(C(C)(C)OC2=CC=C(C=C2)Cl)=O
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Synonyms
Eugenol-clofibrate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CF-Eugenol Related Classifications
HY-190718 Related Classifications
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