1. GPCR/G Protein
    Metabolic Enzyme/Protease
  2. Adenosine Receptor
    Endogenous Metabolite
  3. Adenosine-2'-monophosphate

Adenosine-2'-monophosphate (Synonyms: 2'-AMP; Adenosine 2'-phosphate; AMP 2'-phosphate)

Cat. No.: HY-124151
Handling Instructions

Adenosine-2'-monophosphate (2'-AMP) is converted by extracellular 2’,3'-CAMP. Adenosine-2'-monophosphate is further metabolized to extracellular adenosine (a mechanism called the extracellular 2’,3’-cAMP-adenosine pathway). Adenosine-2'-monophosphate inhibits LPS-induced TNF-α and CXCL10 production via A2A receptor activation.

For research use only. We do not sell to patients.

Adenosine-2'-monophosphate Chemical Structure

Adenosine-2'-monophosphate Chemical Structure

CAS No. : 130-49-4

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Description

Adenosine-2'-monophosphate (2'-AMP) is converted by extracellular 2’,3'-CAMP. Adenosine-2'-monophosphate is further metabolized to extracellular adenosine (a mechanism called the extracellular 2’,3’-cAMP-adenosine pathway). Adenosine-2'-monophosphate inhibits LPS-induced TNF-α and CXCL10 production via A2A receptor activation[1][2].

IC50 & Target[1][2]

A2A adenosine receptor

 

A2B adenosine receptor

 

Human Endogenous Metabolite

 

In Vitro

Adenosine-2'-monophosphate (2'-AMP) (0-100 µM; daily for 4 days) inhibits proliferation of preglomerular vascular smooth muscle cells and glomerular mesangial cells via A2B receptors[1].
Adenosine-2'-monophosphate (30 μM; 24 hours) inhibits LPS induced (100 ng/ml) TNF-α and CXCL10 production in primary murine microglia[1].

Molecular Weight

347.22

Formula

C₁₀H₁₄N₅O₇P

CAS No.

130-49-4

SMILES

O=[P](O)(O)O[[email protected]]([[email protected]@H]1O)[[email protected]@](N2C3=NC=NC(N)=C3N=C2)([H])O[[email protected]@H]1CO

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Adenosine-2'-monophosphate2'-AMPAdenosine 2'-phosphateAMP 2'-phosphateAdenosine ReceptorEndogenous MetaboliteP1 receptorproliferationmetabolizedLPSCXCL10cAMPPGVSMCGMCInhibitorinhibitorinhibit

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Adenosine-2'-monophosphate
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HY-124151
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