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  3. SP-100030

SP-100030 

Cat. No.: HY-110177
Handling Instructions

SP-100030 is a potent NF-κB and activator protein-1 (AP-1) double inhibitor (IC50s=50 and 50 nM, respectively). SP-100030 inhibits IL-2, IL-8, and TNF-alpha production in Jurkat and other T cell lines. SP-100030 decreases murine collagen-induced arthritis (CIA).

For research use only. We do not sell to patients.

SP-100030 Chemical Structure

SP-100030 Chemical Structure

CAS No. : 154563-54-9

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Description

SP-100030 is a potent NF-κB and activator protein-1 (AP-1) double inhibitor (IC50s=50 and 50 nM, respectively). SP-100030 inhibits IL-2, IL-8, and TNF-alpha production in Jurkat and other T cell lines. SP-100030 decreases murine collagen-induced arthritis (CIA)[1][2].

In Vitro

SP-100030 blocks the production of IL-2 and IL-8 in Jurkat T-cells at the same concentrations as seen in the luciferase assay (IC50≈30 nM)[1].
ELISA and RT-PCR confirmed that IL-2, IL-8, and TNF-alpha production by activated Jurkat and other T cell lines were inhibited by SP100030[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SP100030 (10 mg/kg/day; i.p.; day 21 to day 34) significantly decreased arthritis severity[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six- to 8-wk-old male DBA/1J mice (immunized with type II collagen)[2]
Dosage: 10 mg/kg
Administration: I.p.; daily, starting at day 21 to the end of the study on day 34
Result: Significantly decreased arthritis scores compared with controls; Histologic evaluation of the paws from mice treated from day 20 to 34 showed a trend toward decreased inflammation.
Molecular Weight

437.65

Formula

C₁₄H₅ClF₉N₃O

CAS No.

154563-54-9

SMILES

FC(F)(F)C1=CC(C(F)(F)F)=CC(NC(C2=CN=C(Cl)N=C2C(F)(F)F)=O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SP-100030SP100030SP 100030NF-κBNuclear factor-κBNuclear factor-kappaBproductionIL-2IL-8CIAJurkatcellsTimmunosuppressionInhibitorinhibitorinhibit

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Product Name:
SP-100030
Cat. No.:
HY-110177
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