2. NF-κB
  3. NF-κB
  4. mcIRBP-9

mcIRBP-9 is an orally bioavailable NF-κB inhibitor. mcIRBP-9 reduces the levels of TNF-α, IL-1β and TGF-β1 in renal tissues, and decreases LPS-induced IL-1β production. mcIRBP-9 can be used in research related to diabetic nephropathy and type 2 diabetes mellitus.

For research use only. We do not sell to patients.

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mcIRBP-9

mcIRBP-9 Chemical Structure

CAS No. : 1489241-80-6

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mcIRBP-9 Related Antibodies

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Description

mcIRBP-9 is an orally bioavailable NF-κB inhibitor. mcIRBP-9 reduces the levels of TNF-α, IL-1β and TGF-β1 in renal tissues, and decreases LPS-induced IL-1β production. mcIRBP-9 can be used in research related to diabetic nephropathy and type 2 diabetes mellitus[1].

In Vivo

mcIRBP-9 (1-10 μmol kg−1; p.o.; once daily or single dose; 12 consecutive weeks or short-term) improves glucose clearance in a dose-dependent manner, reduces long-term blood glucose and HbA1c levels, improves survival rate to 100%, and ameliorates diabetic nephropathy in db/db mice via anti-inflammatory and reno-protective effects[1].
mcIRBP-9 (1 μmol kg−1; p.o.; single dose given after LPS challenge) suppresses LPS-induced renal NF-κB activity and systemic IL-1β production in NF-κB transgenic mice, demonstrating anti-inflammatory activity relevant to nephropathy[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NF-κB transgenic (male, 6-week-old)[1]
Dosage: 1 μmol kg-1
Administration: p.o.; single dose given after LPS challenge
Result: Reduced serum IL-1β levels by 69.28 % compared to LPS-only controls.
Suppressed LPS-induced renal NF-κB-dependent luminescent intensities by 61.78 % compared to LPS-only controls.
Molecular Weight

923.11

Formula

C42H74N12O11
CAS No.
Sequence

Ile-Val-Ala-Arg-Pro-Pro-Thr-Ile-Gly
Sequence Shortening

IVARPPTIG
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Purity & Documentation
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mcIRBP-9 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

mcIRBP-91489241-80-6mcIRBP9mcIRBP 9NF-κBNuclear factor-κBNuclear factor-kappaBHbA1crenal cellsLPSdiabetic nephropathyTNF-αtype 2 diabetesTGF-β1db/db miceIL-1βInhibitorinhibitorinhibit

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