mcIRBP-9
mcIRBP-9 is an orally active NF-κB inhibitor. mcIRBP-9 reduces the levels of TNF-α, IL-1β and TGF-β1 in renal tissues, and decreases LPS-induced IL-1β production. mcIRBP-9 can be used in research related to diabetic nephropathy and type 2 diabetes mellitus.
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- CAS No.: 1489241-80-6
- Formule: C42H74N12O11
- Masse moléculaire:923.11
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
mcIRBP-9 (1 μmol kg?1; p.o.; single dose given after LPS challenge) suppresses LPS-induced renal NF-κB activity and systemic IL-1β production in NF-κB transgenic mice, demonstrating anti-inflammatory activity relevant to nephropathy[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NF-κB transgenic (male, 6-week-old)[1]
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Dosage:1 μmol kg-1
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Administration:p.o.; single dose given after LPS challenge
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Result:Reduced serum IL-1β levels by 69.28 % compared to LPS-only controls.
Suppressed LPS-induced renal NF-κB-dependent luminescent intensities by 61.78 % compared to LPS-only controls.
Chemical Information
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CAS No. 1489241-80-6
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Masse moléculaire 923.11
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Formule C42H74N12O11
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Sequence
Ile-Val-Ala-Arg-Pro-Pro-Thr-Ile-Gly
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Sequence Shortening
IVARPPTIG
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
mcIRBP-9 Related Classifications
HY-P11736 Related Classifications
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