LX-3
Based on 1 publication(s) in Google Scholar
LX-3 is a selective activator of the p38 MAPK signaling pathway and activates EGFP reporter genes that are silenced by DNA methylation, such as TNF, EGR1, LY6K, and ISG20.
For research use only. We do not sell to patients.
- Purity: 98.08%
- CAS No.: 380645-50-1
- Formula: C20H13BrN4OS
- Molecular Weight:437.31
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Immunology/Inflammation Compound Library
HY-L007
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Kinase Inhibitor Library
HY-L009
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MAPK Compound Library
HY-L010
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Anti-Cancer Compound Library
HY-L025
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Reprogramming Compound Library
HY-L039
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HY-L045
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HY-L059
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Publications Citing Use of MedChemExpress (MCE) LX-3
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Biological Activity
Chemical Information
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CAS No. 380645-50-1
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Appearance Solid
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Molecular Weight 437.31
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Formula C20H13BrN4OS
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Color Off-white to light yellow
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SMILES
BrC1=CC=C(C(CN2C3=NC(C4=CC=CS4)=NN3C5=CC=CC=C25)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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J Environ Manage
New insights into quercetin's attenuation of TBBPA-induced injury to MCEC cells: Involvement of the p38/NF-κB pathway and pyroptosis. [Abstract]2025 Feb 10:376:124425. PMID: 39933375
Solvent & Solubility
DMSO : 50 mg/mL (114.34 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 3.75 mg/mL (8.58 mM); Clear solution
This protocol yields a clear solution of ≥ 3.75 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (37.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (280 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2867 mL | 11.4335 mL | 22.8671 mL | 57.1677 mL |
| 5 mM | 0.4573 mL | 2.2867 mL | 4.5734 mL | 11.4335 mL | |
| 10 mM | 0.2287 mL | 1.1434 mL | 2.2867 mL | 5.7168 mL | |
| 15 mM | 0.1524 mL | 0.7622 mL | 1.5245 mL | 3.8112 mL | |
| 20 mM | 0.1143 mL | 0.5717 mL | 1.1434 mL | 2.8584 mL | |
| 25 mM | 0.0915 mL | 0.4573 mL | 0.9147 mL | 2.2867 mL | |
| 30 mM | 0.0762 mL | 0.3811 mL | 0.7622 mL | 1.9056 mL | |
| 40 mM | 0.0572 mL | 0.2858 mL | 0.5717 mL | 1.4292 mL | |
| 50 mM | 0.0457 mL | 0.2287 mL | 0.4573 mL | 1.1434 mL | |
| 60 mM | 0.0381 mL | 0.1906 mL | 0.3811 mL | 0.9528 mL | |
| 80 mM | 0.0286 mL | 0.1429 mL | 0.2858 mL | 0.7146 mL | |
| 100 mM | 0.0229 mL | 0.1143 mL | 0.2287 mL | 0.5717 mL |
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