7-Acetyl paclitaxel
Based on 1 Customer Validation
7-Acetyl paclitaxel is a microtubule depolymerization inhibitor which inhibits calcium-induced microtubule depolymerization. 7-Acetyl paclitaxel reduces the growth of J774.2 macrophages (IC50 ~ 60 nM) and increases the levels of nitric oxide (NO) and TNF in isolated mouse peritoneal macrophages.
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- Pureté: 98.35%
- CAS No.: 92950-39-5
- Formule: C49H53NO15
- Masse moléculaire:895.94
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| J774.2 | ED50 |
9 x 10-8 M
Compound: 11
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Cytotoxicity against mouse J774.2 cells
Cytotoxicity against mouse J774.2 cells
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10.1021/np50067a001 |
| KB | ED50 |
4 ng/mL
Compound: 3
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Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
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[PMID: 2898009] |
| KB | ED50 |
4 x 10-3 μg/mL
Compound: 3
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Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
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[PMID: 2898009] |
Chemical Information
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CAS No. 92950-39-5
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Appearance Solid
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Masse moléculaire 895.94
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Formule C49H53NO15
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Color White to off-white
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SMILES
CC(O[C@]([C@@]1([H])C[C@@H]2OC(C)=O)(CO1)[C@]([C@@H]([C@@](C3(C)C)(C[C@@H]4OC([C@H](O)[C@H](C5=CC=CC=C5)NC(C6=CC=CC=C6)=O)=O)O)OC(C7=CC=CC=C7)=O)([H])[C@@]2(C([C@@H](C3=C4C)OC(C)=O)=O)C)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 100 mg/mL (111.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (2.79 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (279 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1161 mL | 5.5807 mL | 11.1615 mL | 27.9037 mL |
| 5 mM | 0.2232 mL | 1.1161 mL | 2.2323 mL | 5.5807 mL | |
| 10 mM | 0.1116 mL | 0.5581 mL | 1.1161 mL | 2.7904 mL | |
| 15 mM | 0.0744 mL | 0.3720 mL | 0.7441 mL | 1.8602 mL | |
| 20 mM | 0.0558 mL | 0.2790 mL | 0.5581 mL | 1.3952 mL | |
| 25 mM | 0.0446 mL | 0.2232 mL | 0.4465 mL | 1.1161 mL | |
| 30 mM | 0.0372 mL | 0.1860 mL | 0.3720 mL | 0.9301 mL | |
| 40 mM | 0.0279 mL | 0.1395 mL | 0.2790 mL | 0.6976 mL | |
| 50 mM | 0.0223 mL | 0.1116 mL | 0.2232 mL | 0.5581 mL | |
| 60 mM | 0.0186 mL | 0.0930 mL | 0.1860 mL | 0.4651 mL | |
| 80 mM | 0.0140 mL | 0.0698 mL | 0.1395 mL | 0.3488 mL | |
| 100 mM | 0.0112 mL | 0.0558 mL | 0.1116 mL | 0.2790 mL |
7-Acetyl paclitaxel Related Classifications
HY-138056 Related Classifications
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