7-Acetyl paclitaxel

Cat. No.: HY-138056 Purity: 98.35%: Data Sheet
COA

SDS
Handling Instructions
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7-Acetyl paclitaxel is a microtubule depolymerization inhibitor which inhibits calcium-induced microtubule depolymerization. 7-Acetyl paclitaxel reduces the growth of J774.2 macrophages (IC₅₀ ~ 60 nM) and increases the levels of nitric oxide (NO) and TNF in isolated mouse peritoneal macrophages.

For research use only. We do not sell to patients.

7-Acetyl paclitaxel Chemical Structure

CAS No. : 92950-39-5

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
J774.2	ED₅₀	9 x 10^-8 M Compound: 11	Cytotoxicity against mouse J774.2 cells Cytotoxicity against mouse J774.2 cells	10.1021/np50067a001
KB	ED₅₀	4 x 10^-3 μg/mL Compound: 3	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 2898009]

Molecular Weight

895.94

Formula

C₄₉H₅₃NO₁₅

CAS No.

92950-39-5

Appearance

Solid

Color

White to off-white

SMILES

CC(O[C@]([C@@]1([H])C[C@@H]2OC(C)=O)(CO1)[C@]([C@@H]([C@@](C3(C)C)(C[C@@H]4OC([C@H](O)[C@H](C5=CC=CC=C5)NC(C6=CC=CC=C6)=O)=O)O)OC(C7=CC=CC=C7)=O)([H])[C@@]2(C([C@@H](C3=C4C)OC(C)=O)=O)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (111.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1161 mL	5.5807 mL	11.1615 mL
5 mM	0.2232 mL	1.1161 mL	2.2323 mL
10 mM	0.1116 mL	0.5581 mL	1.1161 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (2.79 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (2.79 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.35%

Select Batch:

Data Sheet (279 KB) SDS (393 KB)

COA (263 KB) HNMR (335 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Ojima I, et al. Structure-activity relationship study of taxoids for their ability to activate murine macrophages as well as inhibit the growth of macrophage-like cells. Bioorg Med Chem. 2003 Jul 3;11(13):2867-88. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.1161 mL	5.5807 mL	11.1615 mL	27.9037 mL
	5 mM	0.2232 mL	1.1161 mL	2.2323 mL	5.5807 mL
	10 mM	0.1116 mL	0.5581 mL	1.1161 mL	2.7904 mL
	15 mM	0.0744 mL	0.3720 mL	0.7441 mL	1.8602 mL
	20 mM	0.0558 mL	0.2790 mL	0.5581 mL	1.3952 mL
	25 mM	0.0446 mL	0.2232 mL	0.4465 mL	1.1161 mL
	30 mM	0.0372 mL	0.1860 mL	0.3720 mL	0.9301 mL
	40 mM	0.0279 mL	0.1395 mL	0.2790 mL	0.6976 mL
	50 mM	0.0223 mL	0.1116 mL	0.2232 mL	0.5581 mL
	60 mM	0.0186 mL	0.0930 mL	0.1860 mL	0.4651 mL
	80 mM	0.0140 mL	0.0698 mL	0.1395 mL	0.3488 mL
	100 mM	0.0112 mL	0.0558 mL	0.1116 mL	0.2790 mL