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  4. Furathiocarb

Furathiocarb is a carbamate pro-insecticide and a contact allergen. Furathiocarb is commonly used in studies related to contact allergy. Furathiocarb induces significant proliferation of MHC II-positive B cells in auricular lymph node cells and induces the production of Th1 cytokines (such as IL-2, TNF-γ and IFN-γ). However, Furathiocarb does not induce respiratory allergy in mice. After absorption through the abdominal skin of isolated rats, Furathiocarb is completely metabolized into carbofuran, and its permeation amount increases with time and dosage. The skin permeation rates of both emulsifiable concentrate (EC) and wettable powder (WP) formulations of Furathiocarb are higher than that of Furathiocarb itself, with no significant difference between the two formulations.

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Furathiocarb

Furathiocarb Chemical Structure

CAS No. : 65907-30-4

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Furathiocarb Related Antibodies

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Description

Furathiocarb is a carbamate pro-insecticide and a contact allergen. Furathiocarb is commonly used in studies related to contact allergy. Furathiocarb induces significant proliferation of MHC II-positive B cells in auricular lymph node cells and induces the production of Th1 cytokines (such as IL-2, TNF-γ and IFN-γ). However, Furathiocarb does not induce respiratory allergy in mice. After absorption through the abdominal skin of isolated rats, Furathiocarb is completely metabolized into carbofuran, and its permeation amount increases with time and dosage. The skin permeation rates of both emulsifiable concentrate (EC) and wettable powder (WP) formulations of Furathiocarb are higher than that of Furathiocarb itself, with no significant difference between the two formulations[1][2].

In Vivo

Furathiocarb (0.1-3%; topical administration; once daily for 3 consecutive days) acts as a skin sensitizer in female CBA/Jn mice. A positive local lymph node assay response is observed at the 3% dose, with an EC3 value of 1.08%[1].
After long-term skin sensitization and intratracheal challenge in female BALB/c mice with Furathiocarb (1% for sensitization, 0.01-0.1% for challenge; sensitization is administered topically, challenge is administered intratracheally; sensitization is performed on days 1-3, 8-10, and 15-17, with a single challenge dose given on day 31), no significant Th2 activation is observed in lung-associated lymph nodes, and no respiratory allergen immune characteristics are induced[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice with Allergic contact dermatitis (female, 7 weeks old)[1]
Dosage: 1% (sensitization); 0.01% (challenge), 0.1% (challenge)
Administration: topical; on days 1-3, 8-10, 15-17 (sensitization); topical; single dose on day 31 (challenge)
Result: Did not cause statistically significant increases in total serum IgE levels in any furathiocarb-treated groups relative to controls.
Caused statistically significant increases in total lymphocyte counts, MHC Class II-positive B-cell counts, and IgE-positive B-cell counts in auricular lymph nodes at 0.1% challenge dose (after 1% sensitization) relative to control groups.
Caused IgE-positive B-cell counts to be significantly higher than in the low-dose challenge group at 0.1% challenge dose (after 1% sensitization).
Caused statistically significant increases in total lymphocyte counts and MHC Class II-positive B-cell counts in auricular lymph nodes at 0.01% challenge dose (after 1% sensitization) relative to non-sensitized controls.
Induced statistically significant increases in Th1 cytokines (IL-2, TNF-α, IFN-γ) and Th2 cytokines (IL-4, IL-5, IL-10, IL-13) in ex situ culture of auricular lymph node cells relative to controls, though Th2 cytokine responses were milder than those induced by 2,4-D.
Animal Model: BALB/c mice with Respiratory allergy (female, 7 weeks old)[1]
Dosage: 1% (sensitization); 0.01% (challenge), 0.1% (challenge)
Administration: topical; on days 1-3, 8-10, 15-17 (sensitization); intratracheal; single dose on day 31 (challenge)
Result: Did not cause statistically significant increases in total IgE levels in serum or BALF in any furathiocarb-treated groups relative to controls.
Did not cause elevations in total or differential cell counts (eosinophils, neutrophils, macrophages) in BALF, aside from a mild, statistically significant increase in MIP-1β levels in the high-dose challenge group relative to controls.
Did not cause statistically significant increases in IgE-positive B-cell or MHC Class II-positive B-cell counts in lung-associated lymph nodes.
Did not induce statistically significant increases in Th2 cytokines (IL-4, IL-10, IL-13) in ex situ culture of lung-associated lymph node cells relative to controls.
Molecular Weight

382.48

Formula

C18H26N2O5S
CAS No.
SMILES

O=C(OC1=CC=CC2=C1OC(C)(C)C2)N(SN(C(=O)OCCCC)C)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Furathiocarb Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Furathiocarb65907-30-4InsecticideIL-2MHC Class II-positive B-cellsCBA/Jn miceTh1 cytokinescontact allergyauricular lymph node cellsrat abdominal skinIFN-γTNF-γBALB/c miceInhibitorinhibitorinhibit

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