65907-30-4
Chemical Structure
Furathiocarb
- CAS No.: 65907-30-4
- Formula:C18H26N2O5S
- Molecular Weight:382.48
IUPAC Name: butyl (2,2-dimethyl-2,3-dihydrobenzofuran-7-yl) thiobis(methylcarbamate)
InChIKey: HAWJXYBZNNRMNO-UHFFFAOYSA-N
SMILES: O=C(OC1=CC=CC2=C1OC(C)(C)C2)N(SN(C(=O)OCCCC)C)C
Biological Activity: Furathiocarb is a carbamate pro-insecticide and a contact allergen. Furathiocarb is commonly used in studies related to contact allergy. Furathiocarb induces significant proliferation of MHC II-positive B cells in auricular lymph node cells and induces the production of Th1 cytokines (such as IL-2, TNF-γ and IFN-γ). However, Furathiocarb does not induce respiratory allergy in mice. After absorption through the abdominal skin of isolated rats, Furathiocarb is completely metabolized into carbofuran, and its permeation amount increases with time and dosage. The skin permeation rates of both emulsifiable concentrate (EC) and wettable powder (WP) formulations of Furathiocarb are higher than that of Furathiocarb itself, with no significant difference between the two formulations[1][2].
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Furathiocarb | Furathiocarb is a carbamate pro-insecticide and a contact allergen. Furathiocarb is commonly used in studies related to contact allergy. Furathiocarb induces significant proliferation of MHC II-positive B cells in auricular lymph node cells and induces the production of Th1 cytokines (such as IL-2, TNF-γ and IFN-γ). However, Furathiocarb does not induce respiratory allergy in mice. After absorption through the abdominal skin of isolated rats, Furathiocarb is completely metabolized into carbofuran, and its permeation amount increases with time and dosage. The skin permeation rates of both emulsifiable concentrate (EC) and wettable powder (WP) formulations of Furathiocarb are higher than that of Furathiocarb itself, with no significant difference between the two formulations. | |||||||||||||||||||||
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- [1]. Fukuyama T, et al. Allergic reaction induced by dermal and/or respiratory exposure to low-dose phenoxyacetic acid, organophosphorus, and carbamate pesticides[J]. Toxicology, 2009, 261(3): 152-161.
- [2]. Liu KH, et al. In vitro dermal penetration study of carbofuran, carbosulfan, and furathiocarb. Arch Toxicol. 2003;77(5):255-260. [Content Brief]
Keywords
