2. Immunology/Inflammation Apoptosis
  3. Interleukin Related TNF Receptor
  4. Divaricatol

Divaricatol is an orally ative chromone natural product and an active component in Saposhnikovia divaricata. Divaricatol reduces the release of pro-inflammatory cytokines and restores immune homeostasis by stably binding to 5KIR (a target of the TNF/IL-17 pathway). Divaricatol exerts analgesic effects in mouse models. Divaricatol can be used in the research of pain, diarrhea-predominant irritable bowel syndrome (IBS-D) and qi deficiency syndrome.

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Divaricatol

Divaricatol Chemical Structure

CAS No. : 331433-08-0

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Divaricatol Related Antibodies

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Description

Divaricatol is an orally ative chromone natural product and an active component in Saposhnikovia divaricata. Divaricatol reduces the release of pro-inflammatory cytokines and restores immune homeostasis by stably binding to 5KIR (a target of the TNF/IL-17 pathway). Divaricatol exerts analgesic effects in mouse models. Divaricatol can be used in the research of pain, diarrhea-predominant irritable bowel syndrome (IBS-D) and qi deficiency syndrome[1][2][3].

In Vivo

Divaricatol (1-5 mg/kg; p.o.; single dose) exhibits potent analgesic activity in the acetic acid-induced writhing model in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ddy (Male, 4 weeks old, 24–36 g, acetic acid-induced writhing model)[1]
Dosage: 1, 5 mg/kg
Administration: p.o.; single dose
Result: Showed potent analgesic effect at oral doses of 1 and 5 mg/kg.
Molecular Weight

334.32

Formula

C17H18O7
CAS No.
SMILES

OC1=C2C(OC(C)([C@H](C2)OC(C)=O)C)=CC3=C1C(C=C(O3)CO)=O
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Divaricatol Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Divaricatol331433-08-0Interleukin RelatedTNF ReceptorILTumor Necrosis Factor ReceptorTNFRinflammatory pathwaysmiceimmune homeostasisqi deficiency syndromeirritable bowel syndrome with diarrhea (IBS-D)5KIR proteinTongxie YaofangQishenbuqi capsulesInhibitorinhibitorinhibit

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