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Cat. No.: HY-153330

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TNF-α-IN-10

TNF-α-IN-10 (compound 8a) is a IL-6 and TNF-α inhibitor. TNF-α-IN-10 shows anti-inflammatory activity.

For research use only. We do not sell to patients.

CAS No.: 2247720-56-3
Formula: C₁₇H₁₄O₄
Molecular Weight:282.29

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

TNF-α-IN-10 Chemical Structure

CAS No.: 2247720-56-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

TNF-α-IN-10 (compound 8a) is a IL-6 and TNF-α inhibitor. TNF-α-IN-10 shows anti-inflammatory activity^[1].

IC₅₀ & Target

IL-6

All Interleukin Related Isoforms :

All TNF Receptor Isoforms :

In Vitro

TNF-α-IN-10 (compound 8a) (10 μM) shows inhibition rates on the release of IL-6 and TNF-α from RAW 264.7 macrophages are 40% and 44.65%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2247720-56-3
Molecular Weight 282.29
Formula C₁₇H₁₄O₄
SMILES

O=C1/C(CC2=C1C(O)=CC=C2)=C/C3=CC=C(O)C(OC)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhi-Guo Liu, et al. A kind of 2- Asia-(3- methoxyl group -4- hydroxyls)-benzyl -1- indones analogs and application. CN108516929A.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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TNF-α-IN-10

All Interleukin Related Isoforms

All TNF Receptor Isoforms