Cannabitwinol
Cannabitwinol is a selective thermosensitive TRP modulator and NF-κB inhibitor. Cannabitwinol inhibits TNFα-induced NF-κB-driven transcription and TNFα-induced IL-8 release, and exhibits anti-inflammatory and antioxidant activities. Cannabitwinol shows selectivity for cold-activated TRP channels, activating TRPA1 (EC50 = 3.0 μM) and antagonizing TRPM8 (IC50 = 3.9 μM), but has no significant affinity for heat-activated TRP channels such as TRPV1 and TRPV2. Cannabitwinol can be used in research related to inflammatory skin diseases, cold allodynia, and hyperalgesia.
For research use only. We do not sell to patients.
- CAS No.: 2699950-81-5
- Formula: C43H60O4
- Molecular Weight:640.93
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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NF-κB |
IL-8 |
TRPA1 3.0 μM (EC50) |
TRPM8 3.9 μM (IC50) |
Cannabitwinol (0.5-20 μM; 6 h) inhibits TNFα-induced IL-8 release (IC50 = 6.39 μM) and NF-κB-driven transcription (IC50 = 19.8 μM) in HaCaT cells, with significant NF-κB inhibition observed at 20 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HaCaT human keratinocytes
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Concentration:0.5, 1, 2.5, 5, 10 and 20 μM
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Incubation Time:6 h (cotreatment with TNFα)
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Result:Inhibited TNFα-induced IL-8 release with an IC50 of 6.39 μM in a concentration-dependent manner.
Inhibited TNFα-induced NF-κB-driven transcription with an IC50 of 19.8 μM, with a statistically significant effect observed only at 20 μM.
Chemical Information
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CAS No. 2699950-81-5
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Molecular Weight 640.93
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Formula C43H60O4
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SMILES
CC([C@H]1[C@H](C2=C(C(CC3=C(C=C(C([C@H]4[C@@H](CCC(C)=C4)C(C)=C)=C3O)O)CCCCC)=C(C=C2O)CCCCC)O)C=C(CC1)C)=C
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Synonyms
CBDD
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1].
Pozzi L, et al. Cannabizetol, a Novel Cannabinoid: Chemical Synthesis, Anti-inflammatory Activity and Extraction from Cannabis sativa L. J Nat Prod. 2025 Oct 24;88(10):2451-2459.
[Content Brief]
[2].
Chianese G, et al. Cannabitwinol, a Dimeric Phytocannabinoid from Hemp, Cannabis sativa L., Is a Selective Thermo-TRP Modulator. J Nat Prod. 2020 Sep 25;83(9):2727-2736.
[Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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