Cannabitwinol  (Synonyms: CBDD)

Cannabitwinol is a selective thermosensitive TRP modulator and NF-κB inhibitor. Cannabitwinol inhibits TNFα-induced NF-κB-driven transcription and TNFα-induced IL-8 release, and exhibits anti-inflammatory and antioxidant activities. Cannabitwinol shows selectivity for cold-activated TRP channels, activating TRPA1 (EC₅₀ = 3.0 μM) and antagonizing TRPM8 (IC₅₀ = 3.9 μM), but has no significant affinity for heat-activated TRP channels such as TRPV1 and TRPV2. Cannabitwinol can be used in research related to inflammatory skin diseases, cold allodynia, and hyperalgesia^[1][2].

Cannabitwinol (0.5-20 μM; 6 h) inhibits TNFα-induced IL-8 release (IC₅₀ = 6.39 μM) and NF-κB-driven transcription (IC₅₀ = 19.8 μM) in HaCaT cells, with significant NF-κB inhibition observed at 20 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

640.93

C₄₃H₆₀O₄

2699950-81-5

CC([C@H]1[C@H](C2=C(C(CC3=C(C=C(C([C@H]4[C@@H](CCC(C)=C4)C(C)=C)=C3O)O)CCCCC)=C(C=C2O)CCCCC)O)C=C(CC1)C)=C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Pozzi L, et al. Cannabizetol, a Novel Cannabinoid: Chemical Synthesis, Anti-inflammatory Activity and Extraction from Cannabis sativa L. J Nat Prod. 2025 Oct 24;88(10):2451-2459.
   [Content Brief]

  [2]. Chianese G, et al. Cannabitwinol, a Dimeric Phytocannabinoid from Hemp, Cannabis sativa L., Is a Selective Thermo-TRP Modulator. J Nat Prod. 2020 Sep 25;83(9):2727-2736.
   [Content Brief]