2699950-81-5
Chemical Structure
Cannabitwinol
Synonym(s): CBDD
- CAS No.: 2699950-81-5
- Formula:C43H60O4
- Molecular Weight:640.93
InChIKey: UMJIRNQSAUOZKO-HEZKMHOLSA-N
SMILES: CC([C@H]1[C@H](C2=C(C(CC3=C(C=C(C([C@H]4[C@@H](CCC(C)=C4)C(C)=C)=C3O)O)CCCCC)=C(C=C2O)CCCCC)O)C=C(CC1)C)=C
Biological Activity: Cannabitwinol is a selective thermosensitive TRP modulator and NF-κB inhibitor. Cannabitwinol inhibits TNFα-induced NF-κB-driven transcription and TNFα-induced IL-8 release, and exhibits anti-inflammatory and antioxidant activities. Cannabitwinol shows selectivity for cold-activated TRP channels, activating TRPA1 (EC50 = 3.0 μM) and antagonizing TRPM8 (IC50 = 3.9 μM), but has no significant affinity for heat-activated TRP channels such as TRPV1 and TRPV2. Cannabitwinol can be used in research related to inflammatory skin diseases, cold allodynia, and hyperalgesia[1][2].
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Cannabitwinol | Cannabitwinol is a selective thermosensitive TRP modulator and NF-κB inhibitor. Cannabitwinol inhibits TNFα-induced NF-κB-driven transcription and TNFα-induced IL-8 release, and exhibits anti-inflammatory and antioxidant activities. Cannabitwinol shows selectivity for cold-activated TRP channels, activating TRPA1 (EC50 = 3.0 μM) and antagonizing TRPM8 (IC50 = 3.9 μM), but has no significant affinity for heat-activated TRP channels such as TRPV1 and TRPV2. Cannabitwinol can be used in research related to inflammatory skin diseases, cold allodynia, and hyperalgesia. | |||||||||||||||||||||
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References
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[1]. Pozzi L, et al. Cannabizetol, a Novel Cannabinoid: Chemical Synthesis, Anti-inflammatory Activity and Extraction from Cannabis sativa L. J Nat Prod. 2025 Oct 24;88(10):2451-2459.
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[2]. Chianese G, et al. Cannabitwinol, a Dimeric Phytocannabinoid from Hemp, Cannabis sativa L., Is a Selective Thermo-TRP Modulator. J Nat Prod. 2020 Sep 25;83(9):2727-2736.
[Content Brief]
