2699950-81-5

Cannabitwinol Chemical Structure
2699950-81-5

Chemical Structure

Cannabitwinol

Synonym(s): CBDD

  • CAS No.: 2699950-81-5
  • Formula:C43H60O4
  • Molecular Weight:640.93

InChIKey: UMJIRNQSAUOZKO-HEZKMHOLSA-N

SMILES: CC([C@H]1[C@H](C2=C(C(CC3=C(C=C(C([C@H]4[C@@H](CCC(C)=C4)C(C)=C)=C3O)O)CCCCC)=C(C=C2O)CCCCC)O)C=C(CC1)C)=C

Biological Activity: Cannabitwinol is a selective thermosensitive TRP modulator and NF-κB inhibitor. Cannabitwinol inhibits TNFα-induced NF-κB-driven transcription and TNFα-induced IL-8 release, and exhibits anti-inflammatory and antioxidant activities. Cannabitwinol shows selectivity for cold-activated TRP channels, activating TRPA1 (EC50 = 3.0 μM) and antagonizing TRPM8 (IC50 = 3.9 μM), but has no significant affinity for heat-activated TRP channels such as TRPV1 and TRPV2. Cannabitwinol can be used in research related to inflammatory skin diseases, cold allodynia, and hyperalgesia[1][2].

Cat. No. Product Name Purity Description Pricing
HY-179432 		Cannabitwinol Cannabitwinol is a selective thermosensitive TRP modulator and NF-κB inhibitor. Cannabitwinol inhibits TNFα-induced NF-κB-driven transcription and TNFα-induced IL-8 release, and exhibits anti-inflammatory and antioxidant activities. Cannabitwinol shows selectivity for cold-activated TRP channels, activating TRPA1 (EC50 = 3.0 μM) and antagonizing TRPM8 (IC50 = 3.9 μM), but has no significant affinity for heat-activated TRP channels such as TRPV1 and TRPV2. Cannabitwinol can be used in research related to inflammatory skin diseases, cold allodynia, and hyperalgesia.
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