Zaluzanin C
Zaluzanin C is a sesquiterpene lactone and antifungal agent. Zaluzanin C is isolated from the leaves of Vernonia arborea. Zaluzanin C inhibits mtROS-mediated NF-κB activity, as well as LPS- and TNF-α-induced mtROS production. Zaluzanin C alleviates mtROS-mediated mitochondrial dysfunction, enhances Mitophagy, and increases the mRNA levels of fatty acid oxidation genes and mitochondrial biogenesis factors. Zaluzanin C inhibits the formation of advanced glycation end products and α-glucosidase activity. Zaluzanin C improves intracellular lipid accumulation. Zaluzanin C exhibits anti-inflammatory, antioxidant, antifungal, anticancer and pro-osteogenic activities. Zaluzanin C can be used in studies related to non-alcoholic fatty liver disease and obesity.
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- CAS. Nr.: 16838-87-2
- Formel: C15H18O3
- Molecular Weight:246.30
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[2]|
α‑glucosidase |
In Vitro
Zaluzanin C (2.5-10 μM; 60 h) exhibits no cytotoxicity or growth inhibitory effect on immortalized mouse Kupffer cells even at concentrations up to 10 μM[1].
Zaluzanin C (10 μM) inhibits LPS-induced mitochondrial ROS production in immortalized mouse Kupffer cells and maintains SOD1 protein levels at a concentration of 10 μM[1].
Zaluzanin C (10 μM; 6 h) inhibits mtROS-mediated NF-κB signaling pathway, reduces the expression of pro-inflammatory genes, and suppresses TNF-α production in immortalized mouse Kupffer cells at a concentration of 10 μM[1].
Zaluzanin C (10 μM; 6-24 h) inhibits TNF-α-induced mitochondrial ROS production in Hep3B cells and primary mouse hepatocytes at a concentration of 10 μM[1].
Zaluzanin C (10 μM; 24 h) enhances CCCP-induced mitophagy in Hep3B cells at a concentration of 10 μM[1].
Zaluzanin C (10 μM; 24 h) upregulates the expression of fatty acid oxidation genes and alleviates TNF-α-induced lipid accumulation in Hep3B cells and primary mouse hepatocytes at a concentration of 10 μM[1].
Zaluzanin C (0-100 μM; 48 h) shows no activity against breast cancer MCF7 cells, with an IC50 > 100 μM[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Immortalized Mouse Kupffer Cells (ImKCs)
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Concentration:2.5-10 μM (cytotoxicity readout); 10 μM (growth monitoring)
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Incubation Time:60 h (growth monitoring)
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Result:Exhibited no toxicity and no growth inhibitory effect at concentrations up to 10 μM.
Showed no difference in OD values between 10 μM ZC and vehicle-treated ImKCs over 60 h.
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Cell Line:human breast cancer MCF7 cells
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Concentration:0-100 μM
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Incubation Time:48 h
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Result:Showed no antiproliferative activity against MCF7 cells, with an IC50 value greater than 100 μM.
Chemical Information
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CAS. Nr. 16838-87-2
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Molecular Weight 246.30
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Formel C15H18O3
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SMILES
C=C1[C@]2([H])[C@]3([H])[C@](CCC([C@]2([H])C[C@@H]1O)=C)([H])C(C(O3)=O)=C
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Jung JW, et al. Zaluzanin C Alleviates Inflammation and Lipid Accumulation in Kupffer Cells and Hepatocytes by Regulating Mitochondrial ROS. Molecules. 2023;28(22):7484. [Content Brief]
[2]. Kwak SH, et al. Zaluzanin C Inhibits Differentiation of 3T3-L1 Preadipocytes into Mature Adipocytes. J Obes Metab Syndr. 2019 Jun;28(2):105-111. [Content Brief]
[3]. Valkute TR, et al. Synthesis and anticancer studies of Michael adducts and Heck arylation products of sesquiterpene lactones, zaluzanin D and zaluzanin C from Vernonia arborea. RSC Adv. 2018 Nov 14;8(67):38289-38304. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Zaluzanin C Related Classifications
HY-N15415 Related Classifications
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