Zaluzanin C 

Zaluzanin C is a sesquiterpene lactone and antifungal agent. Zaluzanin C is isolated from the leaves of Vernonia arborea. Zaluzanin C inhibits mtROS-mediated NF-κB activity, as well as LPS- and TNF-α-induced mtROS production. Zaluzanin C alleviates mtROS-mediated mitochondrial dysfunction, enhances Mitophagy, and increases the mRNA levels of fatty acid oxidation genes and mitochondrial biogenesis factors. Zaluzanin C inhibits the formation of advanced glycation end products and α-glucosidase activity. Zaluzanin C improves intracellular lipid accumulation. Zaluzanin C exhibits anti-inflammatory, antioxidant, antifungal, anticancer and pro-osteogenic activities. Zaluzanin C can be used in studies related to non-alcoholic fatty liver disease and obesity^[1][2][3].

Zaluzanin C (2.5-10 μM; 60 h) exhibits no cytotoxicity or growth inhibitory effect on immortalized mouse Kupffer cells even at concentrations up to 10 μM^[1].
Zaluzanin C (10 μM) inhibits LPS-induced mitochondrial ROS production in immortalized mouse Kupffer cells and maintains SOD1 protein levels at a concentration of 10 μM^[1].
Zaluzanin C (10 μM; 6 h) inhibits mtROS-mediated NF-κB signaling pathway, reduces the expression of pro-inflammatory genes, and suppresses TNF-α production in immortalized mouse Kupffer cells at a concentration of 10 μM^[1].
Zaluzanin C (10 μM; 6-24 h) inhibits TNF-α-induced mitochondrial ROS production in Hep3B cells and primary mouse hepatocytes at a concentration of 10 μM^[1].
Zaluzanin C (10 μM; 24 h) enhances CCCP-induced mitophagy in Hep3B cells at a concentration of 10 μM^[1].
Zaluzanin C (10 μM; 24 h) upregulates the expression of fatty acid oxidation genes and alleviates TNF-α-induced lipid accumulation in Hep3B cells and primary mouse hepatocytes at a concentration of 10 μM^[1].
Zaluzanin C (0-100 μM; 48 h) shows no activity against breast cancer MCF7 cells, with an IC₅₀ > 100 μM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

246.30

C₁₅H₁₈O₃

16838-87-2

C=C1[C@]2([H])[C@]3([H])[C@](CCC([C@]2([H])C[C@@H]1O)=C)([H])C(C(O3)=O)=C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Jung JW, et al. Zaluzanin C Alleviates Inflammation and Lipid Accumulation in Kupffer Cells and Hepatocytes by Regulating Mitochondrial ROS. Molecules. 2023;28(22):7484.  [Content Brief]

  [2]. Kwak SH, et al. Zaluzanin C Inhibits Differentiation of 3T3-L1 Preadipocytes into Mature Adipocytes. J Obes Metab Syndr. 2019 Jun;28(2):105-111.  [Content Brief]

  [3]. Valkute TR, et al. Synthesis and anticancer studies of Michael adducts and Heck arylation products of sesquiterpene lactones, zaluzanin D and zaluzanin C from Vernonia arborea. RSC Adv. 2018 Nov 14;8(67):38289-38304.  [Content Brief]