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Cat. No.: HY-P12222

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Mca-AQTLTL-Dpa-RSSSQ-NH2

Mca-AQTLTL-Dpa-RSSSQ-NH2 is a fluorescent substrate peptide for TNF-α converting enzyme (TACE), with its peptide sequence spanning the TACE cleavage site of tmTNF. In its intact state, the fluorescence of Mca-AQTLTL-Dpa-RSSSQ-NH2 is quenched; upon cleavage by TACE, a fluorescent signal is released, thereby reflecting TACE enzymatic activity. Mca-AQTLTL-Dpa-RSSSQ-NH2 can be used for studies related to TACE activity and TACE inhibition.

For research use only. We do not sell to patients.

Formula: C₆₉H₁₀₃N₂₁O₂₇
Molecular Weight:1658.68

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Mca-AQTLTL-Dpa-RSSSQ-NH2 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

TACE

All MMP Isoforms :

In Vitro

Mca-AQTLTL-Dpa-RSSSQ-NH2 (50 μM; 37°C; 10 min) serves as a fluorescent substrate for recombinant mouse TACE and produces a fluorescent signal upon cleavage by TACE in the oligopeptide hydrolysis assay; upon addition of 5-HIAA, the fluorescent signal of TACE-mediated substrate cleavage decreases^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

In Vivo

The TACE substrate Mca-AQTLTL-Dpa-RSSSQ-NH₂ (5 μM) demonstrates that PKT enhances anti-TNF efficacy by reducing Tace cleavage activity in intestinal macrophages^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 1658.68
Formula C₆₉H₁₀₃N₂₁O₂₇
SMILES

O=C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CCC(N)=O)=O)CO)=O)CO)=O)CO)=O)CCCNC(N)=N)=O)CNC1=C(C=C(C=C1)[N+]([O-])=O)[N+]([O-])=O)=O)CC(C)C)=O)[C@@H](C)O)=O)CC(C)C)=O)[C@@H](C)O)=O)CCC(N)=O)=O)C)CC(C2=CC=C(OC)C=C2O3)=CC3=O
Sequence

{Mca}-Ala-Gln-Thr-Leu-Thr-Leu-{Dpa}-Arg-Ser-Ser-Ser-Gln-NH2
Sequence Shortening

{Mca}-AQTLTL-{Dpa}--RSSSQ-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Jiang Y, et al. Microbial phosphoketolase promotes histone lactylation to improve anti-TNF therapy efficacy in inflammatory bowel disease. Cell metabolism. 2026 Jul 07;38(7):1443-1459.e6. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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