TLR7/8 antagonist 1
TLR7/8 antagonist 1 (Compound 16c) is a competitive TLR7/8 antagonist with IC50 values of 3.91 μM and 2.19 μM, respectively. TLR7/8 antagonist 1 reduces agonist-induced production of proinflammatory cytokines, including TNFα, IFNγ and IL-1β.
For research use only. We do not sell to patients.
- CAS No.: 2901020-63-9
- Formula: C24H27N5O2
- Molecular Weight:417.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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TLR7 3.91 μM (IC50) |
TLR8 2.19 μM (IC50) |
IL-1β |
TLR7/8 antagonist 1 (16c) (3 μM (agonist 4)) inhibits agonist-induced TLR7 NF-κB activation in HEK-SEAP reporter cells with an IC50 of 3.91 μM[1].
TLR7/8 antagonist 1 (16c) (10 μM (agonist 4)) inhibits agonist-induced TLR8 NF-κB activation in HEK-SEAP reporter cells with an IC50 of 2.19 μM[1].
TLR7/8 antagonist 1 (16c) (up to 10 μM) inhibits agonist-induced IFNγ, TNFα, and IL1β production in hPBMCs in a concentration-dependent manner, with complete inhibition at 10 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2901020-63-9
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Molecular Weight 417.50
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Formula C24H27N5O2
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SMILES
COC(C1=CC2=NC(N)=C3N=C(N(C3=C2C=C1)CC4=CC=C(CN)C=C4)CC(C)C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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