2901020-63-9
2901020-63-9
Chemical Structure
TLR7/8 antagonist 1
- CAS No.: 2901020-63-9
- Formula:C24H27N5O2
- Molecular Weight:417.50
IUPAC Name: 7-hydroxy-1-((4-(2-(4-methylpiperazin-1-yl)ethyl)phenyl)amino)-4-nitroacridin-9(10H)-one
InChIKey: ZLDNOUHDDANJBL-UHFFFAOYSA-N
SMILES: COC(C1=CC2=NC(N)=C3N=C(N(C3=C2C=C1)CC4=CC=C(CN)C=C4)CC(C)C)=O
Biological Activity: TLR7/8 antagonist 1 (Compound 16c) is a competitive TLR7/8 antagonist with IC50 values of 3.91 μM and 2.19 μM, respectively. TLR7/8 antagonist 1 reduces agonist-induced production of proinflammatory cytokines, including TNFα, IFNγ and IL-1β[1].
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TLR7/8 antagonist 1 | TLR7/8 antagonist 1 (Compound 16c) is a competitive TLR7/8 antagonist with IC50 values of 3.91 μM and 2.19 μM, respectively. TLR7/8 antagonist 1 reduces agonist-induced production of proinflammatory cytokines, including TNFα, IFNγ and IL-1β. | |||||||||||||||||||||
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References
Keywords
