1. Apoptosis
    GPCR/G Protein
    Immunology/Inflammation
  2. TNF Receptor
    Prostaglandin Receptor
    COX
  3. Licarin A

Licarin A (Synonyms: (+)-Licarin A)

Cat. No.: HY-N2252
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Licarin A ((+)-Licarin A), a neolignan isolated from various plants, significantly and dose-dependently reduces TNF-α production (IC50=12.6±0.3 μM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells. Anti-allergic effects. Licarin A reduces TNF-α and PGD2 production, and COX-2 expression。

For research use only. We do not sell to patients.

Licarin A Chemical Structure

Licarin A Chemical Structure

CAS No. : 51020-86-1

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Description

Licarin A ((+)-Licarin A), a neolignan isolated from various plants, significantly and dose-dependently reduces TNF-α production (IC50=12.6±0.3 μM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells. Anti-allergic effects. Licarin A reduces TNF-α and PGD2 production, and COX-2 expression[1]

In Vitro

Licarin A is found in plants such as Aristolochia taliscana, Machilus thunbergii and Myristica fragrans, which are used as spices and in folk medicines for nervous and digestive disorders. Licarin A also exhibits anti-inflammatory effects[1].
Licarin A (5-20 μM) reduces TNF-α and prostaglandin D2 (PGD2) secretion via the inhibition of PKCα/βII and p38 MAPK pathways. Licarin A treatment tends to reduce phosphorylated PKCα/βII and p38 MAPK protein levels[1].

Molecular Weight

326.39

Formula

C₂₀H₂₂O₄

CAS No.

51020-86-1

SMILES

OC1=CC=C([[email protected]@H]2OC3=C(OC)C=C(/C=C/C)C=C3[[email protected]]2C)C=C1OC

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Licarin A(+)-Licarin ATNF ReceptorProstaglandin ReceptorCOXTumor Necrosis Factor ReceptorTNFRCyclooxygenaseneolignanTNF-αAnti-allergicPGD2COX-2nervousdigestivedisorderanti-inflammatoryInhibitorinhibitorinhibit

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Licarin A
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