VEGFR-2-IN-47
VEGFR-2-IN-47 (compound 7g) is a potent VEGFR-2 inhibitor with an IC50 value of 0.072 µM. VEGFR-2-IN-47 can induce G2 / M phase cell cycle arrest, promote apoptosis, and boost immunomodulation by downregulating TNF-α expression and upregulating IL-2 levels in MCF-7 cells. VEGFR-2-IN-47 has the potential to be used for the research of cancer such as breast cancer and liver carcinoma .
For research use only. We do not sell to patients.
- Formula: C23H22N6O4
- Molecular Weight:446.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All VEGFR Isoforms
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Biological Activity
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VEGFR2 0.072 μM (IC50) |
VEGFR-2-IN-47 (compound 7g) (48 h) exhibits highly selective antiproliferative activity against MCF-7 and HepG2 cancer cells with IC50s values of 19.35 and 27.89 µM, respectively. VEGFR-2-IN-47 displays low toxicity to a normal cell line (WI38) with an IC50 value of 51.14 µM, indicating a favorable safety profile[1]. VEGFR-2-IN-47(19.35 μM; 72 h) results in MCF-7 cells reduction in G0 / G1 phase and S phase, accumulation in G2 / M phase[1]. VEGFR-2-IN-47 (19.35 μM; 72 h) can promote apoptosis by downregulating Bcl-2 expression and upregulating Bax levels, and boost immunomodulation by downregulating TNF-α expression and upregulating IL-2 levels in MCF-7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 cells
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Concentration:19.35 μM
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Incubation Time:72 hours
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Result:Increased the cell population at the G2 / M phase compared to untreated cells from 16.41 to 24.89 %. Induced a decrease in the cell population at the G0 - G1 phase (from 59.04 to 54.51 %) and S phase (from 24.55 to 20.60 %).
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Cell Line:MCF-7 cells
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Concentration:19.35 μM
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Incubation Time:72 hours
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Result:Showed a significant increase in early and late apoptosis (17.65 and 7.21 %, respectively) compared to untreated cells (0.43 and 1.71 %, respectively).
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Cell Line:MCF-7 cells
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Concentration:19.35 μM
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Incubation Time:72 hours
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Result:Upregulated the expression of Bax by more than 4.5 times and downregulated Bcl-2 by more than 6 times. Exhibited a strong suppressive effect on the TNF-a (2.5 fold) and stimulatory effect on the IL-2 (3.3 fold) compared to the control cells.
Chemical Information
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Molecular Weight 446.46
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Formula C23H22N6O4
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SMILES
CC1=CC=CC(NC(C2=CC=C(C=C2)NC(CN3C(C4=C(N(C3=O)C)N=CN4C)=O)=O)=O)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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