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Enavatuzumab

(Synonyms: PDL192; ABT-361; Anti-TNFRSF12A/TWEAKR/CD266 Reference Antibody (enavatuzumab))
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Enavatuzumab (PDL192; ABT-361) is a humanized IgG1 monoclonal antibody targeting the receptor of TNF-like weak inducer of apoptosis (TWEAK). TWEAK (Fn14; TNFRSF12A), the natural ligand of the TWEAK receptor (TweakR), stimulates multiple cellular responses. Enavatuzumab induces tumor growth inhibition through direct TweakR signaling and antibody dependent cell-mediated cytotoxicity (ADCC). Enavatuzumab can actively recruits and activates myeloid effectors to kill tumor cells. Enavatuzumab inhibits the growth of various human TweakR-positive cancer cell lines and xenografts in vitro and in vivo .

For research use only. We do not sell to patients.

  • Purity : 98.27%
  • CAS No.: 1062149-33-0
  • Molecular Weight:150 kDa
  • Storage:
    Shipping with dry ice

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Enavatuzumab
  • Experimental Validation Results for Enavatuzumab
  • Experimental Validation Results for Enavatuzumab
  • Enavatuzumab Chemical Structure
    Enavatuzumab Chemical Structure
CAS No.: 1062149-33-0
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Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Enavatuzumab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Top Publications Citing

Use of MCE Products

All TNF Receptor Isoforms

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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized TNFRSF12A Protein, Human (HEK293, Fc, HY-P72434) can bind Enavatuzumab. The EC50 for this effect is 3.039 ng/mL.

  • 1/16

    Flow cytometric analysis of 1.5X106 HT-29 cells with Enavatuzumab (HY-P99361, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa, Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Enavatuzumab Chemical Structure
    1/16
  • Enavatuzumab
  • Immobilized TNFRSF12A Protein, Human (HEK293, Fc, HY-P72434) can bind Enavatuzumab. The EC50 for this effect is 3.039 ng/mL.
  • Flow cytometric analysis of 1.5X106 HT-29 cells with Enavatuzumab (HY-P99361, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa, Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).