TNFRSF12A - TNF receptor superfamily member 12A Gene

Also Known as FN14; CD266; TWEAKR

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51330

About TNFRSF12A

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:3,020,368-3,022,383 (from NCBI)

This gene has 7 transcripts (splice variants) and 88 orthologues. Ubiquitous expression in gall bladder (RPKM 21.3), liver (RPKM 18.8) and 23 other tissues.

Summary

Involved in positive regulation of extrinsic apoptotic signaling pathway and regulation of wound healing. Predicted to be located in cell surface and ruffle. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TNFRSF12A Products (1)

mRNA Protein Name
NM_016639.3 NP_057723.1 tumor necrosis factor receptor superfamily member 12A precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11728344 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
21525013 GOA
involved in positive regulation of extrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
21525013 GOA
involved in regulation of wound healing IDA
IDA: Inferred from direct assay
11728344 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNFRSF12A Protein Structure

stn_TNFRSF12A

stn_TNFRSF12A: Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain (1 - 129)

  • 0
  • 100
  • 129 a.a.
Protein Preferred Names Protein Names

tumor necrosis factor receptor superfamily member 12A

  • FGF-inducible 14

TNFRSF12A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TNFRSF12A Q9NP84 TRAF2 Homo sapiens Q12933
Anti Bait CoIP
21525013
Intra
TNFRSF12A Q9NP84 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Array
32296183
Intra
TNFRSF12A Q9NP84 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Prey Pooling
32296183
Intra
TNFRSF12A Q9NP84 BIRC2 Homo sapiens Q13490
Anti Bait CoIP
21525013
Intra
TNFRSF12A Q9NP84 SLC30A2 Homo sapiens Q9BRI3
Y2H Array
31515488
Intra
TNFRSF12A Q9NP84 SLC30A2 Homo sapiens Q9BRI3
Y2H Array
25416956
Intra
TNFRSF12A Q9NP84 SLC30A2 Homo sapiens Q9BRI3
Y2H Array
32296183
Intra
TNFRSF12A Q9NP84 SLC30A2 Homo sapiens Q9BRI3
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TNFRSF12A Proteins

Cat. No. Product Name Accession Purity
HY-P71909 TNFRSF12A Protein, Human Q9NP84-1 (E28-P80) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72434 TNFRSF12A Protein, Human (HEK293, Fc) Q9NP84-1 (E28-W79) ≥ 95%, as determined by reducing SDS-PAGE.

TNFRSF12A Antibodies

Cat. No. Product Name Application Reactivity
HY-P82931 CD266 Antibody (YA2676) WB, IHC-P, IP Human, Mouse, Rat
HY-P82931A CD266 Antibody (YA2676)(PBS only) WB, IHC-P, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Glioblastoma

  • Glioblastoma Multiforme

  • Gbm

  • Adult Glioblastoma Multiforme

  • Grade Iv Adult Astrocytic Tumor

  • Primary Glioblastoma Multiforme

  • Spongioblastoma Multiforme

  • Adult Glioblastoma

  • Primary Glioblastoma
Multiple Sclerosis

  • MS

  • Multiple Sclerosis, Susceptibility To

  • Disseminated Sclerosis

  • Multiple Sclerosis, Disease Progression, Modifier Of

  • Insular Sclerosis

  • Multiple Sclerosis Modifier Of Disease Progression

  • Multiple Sclerosis, Susceptibility To 1

  • Multiple Sclerosis, Susceptibility To, 1

  • Multiple Sclerosis 1

  • Generalized Multiple Sclerosis

  • Multiple Sclerosis Variant

  • Multiple Sclerosis Susceptibility To

  • Cerebrospinal Sclerosis

  • Generalised Multiple Sclerosis

  • Ms - [Multiple Sclerosis]

  • Disseminated Cerebrospinal Sclerosis

  • Disseminated Multiple Sclerosis

  • Disseminated Nervous System Myelosclerosis

  • Multiple Cerebrospinal Sclerosis

  • Multiple Combined Sclerosis

  • Multiple Sclerosis Generalised

  • Disseminated Brain Sclerosis

  • Disseminated Spinal Sclerosis

  • Insular Brain Sclerosis

  • Miliary Brain Sclerosis

  • Multiple Combined Sclerosis Of Spinal Cord

  • Multiple Ascending Sclerosis

  • Multiple Brain Sclerosis

  • Multiple Sclerosis Of Brain Stem

  • Multiple Sclerosis Of The Brain Stem

  • Multiple Sclerosis Of Cord

  • Sclérose En Plaques

  • Plaque Sclerosis

  • Multiple Sclerosis Of The Spinal Cord
Stroke, Ischemic

  • Cerebral Infarction

  • Stroke

  • Ischemic Stroke

  • Cerebrovascular Accident

  • Cerebral Infarction, Susceptibility To

  • Stroke, Ischemic, Susceptibility To

  • Cerebral Infarct

  • Ischemic Stroke, Susceptibility To

  • Stroke, Susceptibility To

  • Cva - Cerebral Infarction

  • ISCHSTR

  • Ischemic Cerebrovascular Accident
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P991439 BIIB023 Inhibitor / Phase 2
HY-P99361 Enavatuzumab Inhibitor 98.27% Phase 1

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14803 TNFRSF12A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17480 Tnfrsf12a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23938 Tnfrsf12a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991433 BIIB036 Activator / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TNFRSF12A VGNC VGNC:47656
Bos taurus TNFRSF12A VGNC VGNC:36162
Mus musculus TNFRSF12A MGD MGI:1351484
Macaca mulatta TNFRSF12A VGNC VGNC:99623
Rattus norvegicus TNFRSF12A RGD RGD:631329
Felis catus TNFRSF12A VGNC VGNC:107825
Others TNFRSF12A NCBI