2. Neuronal Signaling Stem Cell/Wnt MAPK/ERK Pathway Apoptosis Immunology/Inflammation
  3. Cholinesterase (ChE) Amyloid-β ERK TNF Receptor Interleukin Related
  4. AD-35

AD-35 is an orally active anti-Alzheimer's disease (AD) agent with moderate AChE inhibitory activity and metal ion chelating ability. AD-35 exhibits IC50 values for AChE and BuChE of 793 nM and 31428 nM, respectively. AD-35 can form chelates with Cu²⁺ and Fe³⁺, but its chelating ability for Zn²⁺ is relatively weak. AD-35 can inhibit Aβ aggregation and disassemble the formed Aβ aggregates, and inhibit Aβ-induced ERK phosphorylation. AD-35 inhibits neuroinflammation in AD rat models and demonstrates a strong effect in improving cognitive function.

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AD-35

AD-35 Chemical Structure

CAS No. : 1531586-64-7

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AD-35 Related Antibodies

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AChE BChE

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ERK ERK1 ERK2 ERK5 ERK8

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TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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Description

AD-35 is an orally active anti-Alzheimer's disease (AD) agent with moderate AChE inhibitory activity and metal ion chelating ability. AD-35 exhibits IC50 values for AChE and BuChE of 793 nM and 31428 nM, respectively. AD-35 can form chelates with Cu²⁺ and Fe³⁺, but its chelating ability for Zn²⁺ is relatively weak. AD-35 can inhibit Aβ aggregation and disassemble the formed Aβ aggregates, and inhibit Aβ-induced ERK phosphorylation. AD-35 inhibits neuroinflammation in AD rat models and demonstrates a strong effect in improving cognitive function[1].

IC50 & Target[1]

AChE

793 nM (IC50)

IL-1β

 

Clinical Trial
Molecular Weight

503.48

Formula

C24H30N3O7P
CAS No.
SMILES

O=C(N(CCC1CCN(CC2=CC=CC=N2)CC1)C34CC4)C(C3=C5)=CC6=C5OCO6.OP(O)(O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AD-35 Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AD-351531586-64-7AD35AD 35Cholinesterase (ChE)Amyloid-βERKTNF ReceptorInterleukin Relatedβ-amyloid peptideAβAbetaExtracellular signal regulated kinasesTumor Necrosis Factor ReceptorTNFRILAlzheimer's diseaseamyloid-βcognitive impairmentmetal ionsneuroinflammatory responseInhibitorinhibitorinhibit

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