2. TMI-1

TMI-1 is a potent inhibitor of disintegrin metalloenzyme 17 (ADAM17) and other MMPs. TMI-1 inhibits LPS-induced TNF-α secretion in human primary monocytes, and human whole blood. TMI-1 selectively induces caspase-dependent apoptosis in triple negative (TN) and ERBB2-overexpressing breast tumor cell lines.

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TMI-1 Chemical Structure

TMI-1 Chemical Structure

CAS No. : 287403-39-8

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TMI-1 Related Antibodies

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Description

TMI-1 is a potent inhibitor of disintegrin metalloenzyme 17 (ADAM17) and other MMPs. TMI-1 inhibits LPS-induced TNF-α secretion in human primary monocytes, and human whole blood[1]. TMI-1 selectively induces caspase-dependent apoptosis in triple negative (TN) and ERBB2-overexpressing breast tumor cell lines[2].

Molecular Weight

398.50

Formula

C17H22N2O5S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@@H]1N(S(=O)(C2=CC=C(OCC#CC)C=C2)=O)CCSC1(C)C)NO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (250.94 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5094 mL 12.5471 mL 25.0941 mL
5 mM 0.5019 mL 2.5094 mL 5.0188 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.59%

COA (252 KB) HNMR (164 KB) RP-HPLC (169 KB) MS (179 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5094 mL 12.5471 mL 25.0941 mL 62.7353 mL
5 mM 0.5019 mL 2.5094 mL 5.0188 mL 12.5471 mL
10 mM 0.2509 mL 1.2547 mL 2.5094 mL 6.2735 mL
15 mM 0.1673 mL 0.8365 mL 1.6729 mL 4.1824 mL
20 mM 0.1255 mL 0.6274 mL 1.2547 mL 3.1368 mL
25 mM 0.1004 mL 0.5019 mL 1.0038 mL 2.5094 mL
30 mM 0.0836 mL 0.4182 mL 0.8365 mL 2.0912 mL
40 mM 0.0627 mL 0.3137 mL 0.6274 mL 1.5684 mL
50 mM 0.0502 mL 0.2509 mL 0.5019 mL 1.2547 mL
60 mM 0.0418 mL 0.2091 mL 0.4182 mL 1.0456 mL
80 mM 0.0314 mL 0.1568 mL 0.3137 mL 0.7842 mL
100 mM 0.0251 mL 0.1255 mL 0.2509 mL 0.6274 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TMI-1287403-39-8WAY-171318TMI1TMI 1WAY171318WAY 171318Inhibitorinhibitorinhibit

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