1. Metabolic Enzyme/Protease
    Apoptosis
  2. MMP
    Apoptosis
  3. TMI-1

TMI-1 (Synonyms: WAY-171318)

Cat. No.: HY-101448
Handling Instructions

TMI-1 is a potent inhibitor of disintegrin metalloenzyme 17 (ADAM17) and other MMPs. TMI-1 inhibits LPS-induced TNF-α secretion in human primary monocytes, and human whole blood. TMI-1 selectively induces caspase-dependent apoptosis in triple negative (TN) and ERBB2-overexpressing breast tumor cell lines.

For research use only. We do not sell to patients.

TMI-1 Chemical Structure

TMI-1 Chemical Structure

CAS No. : 287403-39-8

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Description

TMI-1 is a potent inhibitor of disintegrin metalloenzyme 17 (ADAM17) and other MMPs. TMI-1 inhibits LPS-induced TNF-α secretion in human primary monocytes, and human whole blood[1]. TMI-1 selectively induces caspase-dependent apoptosis in triple negative (TN) and ERBB2-overexpressing breast tumor cell lines[2].

IC50 & Target

ADAM17

8.4 nM (IC50)

Molecular Weight

398.50

Formula

C17H22N2O5S2

CAS No.
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Storage

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TMI-1
Cat. No.:
HY-101448
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